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TDG
Loading...Anti-TDG Products
- Mouse Anti-TDG Recombinant Antibody (clone 35G8) (MOB-3562z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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- Anti-Mouse TDG Immunohistochemistry Kit (VS-0525-XY7155)
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- Species Reactivity: Human, Mouse, Rat, Bovine, Chicken, Frog
- Target: TDG
- Application: IHC
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- Anti-TDG Immunohistochemistry Kit (VS-0325-XY2263)
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- Species Reactivity: Human, Mouse, Rat
- Target: TDG
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer. Interacts with AICDA and GADD45A.
Molecular function
Activator, Chromatin regulator, Hydrolase
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