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TESK1

Anti-TESK1 Products

Recombinant Mouse anti-Human TESK1 Monoclonal antibody (EML2336) (MOB-2008CT)
- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.

Background

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. [provided by RefSeq, Jul 2008]

Protein class

Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts (via both C- and N-termini) with SPRY4 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:12027893, PubMed:15584898). Interacts with TAOK1; the interaction inhibits TAOK1 kinase activity (By similarity). Interacts (via C-terminus) with SPRED1 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:18216281). Interacts (via C-terminus) with PARVA/PARVIN (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:15817463). Interacts with YWHAB/14-3-3 beta; the interaction is dependent on the phosphorylation of TESK1 Ser-437 and inhibits TESK1 kinase activity (PubMed:11555644). Interacts with SPRY1, SPRY3 and SPRED2 (PubMed:17974561). Interacts (via C-terminus) with SPRY2 (via C-terminus); the interaction disrupts SPRY2 interaction with PPP2CA/PP2A-C, possibly by vesicular sequestration of SPRY2 (PubMed:17974561). Therefore dephosphorylation of SPRY2 by the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme is lost, inhibiting its interaction with GRB2 (PubMed:17974561).

Molecular function

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

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