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TET1
Loading...Anti-TET1 Products
- Rabbit Anti-TET1 Polyclonal Antibody (MRO-2217-CN) (MRO-2217-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IHC, FC
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- Anti-TET1 Immunohistochemistry Kit (VS-0525-XY7176)
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- Species Reactivity: Human
- Target: TET1
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]
Protein class
Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Astrocytes, Oligodendrocytes, Oligodendrocyte precursor cells, Theca cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BEWO, HAP1, K-562, NTERA-2)
Interaction
Interacts with HCFC1 and OGT (By similarity). Interacts with SIN3A; recruits the transcriptional corepressor SIN3A to gene promoters (PubMed:21490601). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (By similarity). Interacts with QSER1 (PubMed:33833093). Interacts with NONO (via DNA-binding domain); this interaction recruits TET1 to genomic loci (By similarity).
Molecular function
Activator, Chromatin regulator, Dioxygenase, DNA-binding, Oxidoreductase, Repressor
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