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TIAM2
Anti-TIAM2 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Protein class
Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids, Cone photoreceptor cells, Excitatory neurons)
Immune cell specificity
Immune cell enhanced (non-classical monocyte, neutrophil)
Cell line specificity
Cell line enhanced (AF22, HDLM-2, RH-30)
Interaction
Interacts with MAP1A, MAP1B, PARP1 and YWHAE. Interacts with CD44, PARD3 and MAPK8IP2 (By similarity).
Molecular function
Guanine-nucleotide releasing factor
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