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TMED10
Anti-TMED10 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
Protein class
Transporters
Predicted location
Membrane
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Predominantly dimeric and to a lesser extent monomeric in the ER (PubMed:12237308). Monomer and dimer in ERGIC and cis-Golgi network (PubMed:12237308). Forms homooligomer (via GOLD domain); the assembly is promoted by direct binding with leaderless cargos and may form a protein channel that facilitates cargo entry into the ERGIC (PubMed:32272059). Forms heterooligomeric complexes with other members of the p24 family such as TMED2, TMED7 and TMED9 (PubMed:9472029, PubMed:10359607, PubMed:20427317, PubMed:32272059). Interacts (via GOLD domain) with TMED2 (via GOLD domain); the complex is required for export of TMED10 from the ER to the cis-Golgi network; the complex is proposed to be involved in cis-Golgi network dynamics and / or biogenesis (PubMed:10852829, PubMed:27569046). Associates with the COPI vesicle coat subunits (coatomer) (PubMed:9472029, PubMed:11056392, PubMed:16940185). Tetramerization of the cytoplasmic domain at the Golgi membrane in vitro; the complex is proposed to interact with COPI coatomer and induce budding of the vesicles (By similarity). Interacts with COPG1; the interaction involves TMED10 homodimer (PubMed:16940185). Interacts with ARF1 (GDP-bound); the interaction probably involves a TMED10 oligomer (PubMed:11726511). Interacts with SEC23A, SEC24B, SEC24C and SEC24D components of the coat protein complex II/COPII, indicative of an association of TMED10 with the COPII vesicle coat (PubMed:9472029). Interacts with CD59 (PubMed:20427317). Interacts with MPPE1/PGAP5; the complex might recruit and sort GPI-anchored proteins to the ER-exit site, or the interaction might lead to recycling of PGAP5 between the ER and the Golgi (PubMed:19837036). Interacts with F2LR1/PAR2 (PubMed:21219331). Interacts with KDELR2/ERD2; the interaction is disrupted by KDELR2 ligand (By similarity). Found in a complex composed at least of SURF4, TMED2 and TMED10 (PubMed:18287528). Associates with the presenilin-dependent gamma-secretase complex (PubMed:16641999). Interacts with STX17; the interaction is direct (PubMed:21545355). Interacts with IL-1; the interaction is direct (PubMed:32272059). Interacts with RAB21 (active GTP-bound form); the interaction is indirect and regulates TMED10 abundance and localization at the Golgi (PubMed:31455601).
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