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TNFAIP1

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For Research Use Only. Not For Clinical Use.


Background

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Pancreatic endocrine cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (CACO-2)

Interaction

Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with RHOB. Interacts with PCNA. Interacts with CSNK2B.

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