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TNFRSF17
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Protein class
Cancer-related genes, CD markers, Disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (Plasma cells)
Immune cell specificity
Group enriched (memory B-cell, naive B-cell, plasmacytoid DC)
Cell line specificity
Cell line enhanced (Karpas-707, RPMI-8226, U-266/70, U-266/84)
Interaction
Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.
Molecular function
Receptor
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