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TNNI3
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Anti-TNNI3 Products
- AbPlus™ Anti-TNNI3 Magnetic Beads (1542.14A2) (VS-0424-XY260)
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- Target: TNNI3
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-TNNI3 Immunohistochemistry Kit (VS-0325-XY2324)
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- Species Reactivity: Human, Rat
- Target: TNNI3
- Application: IHC
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- Anti-Mouse TNNI3 Immunohistochemistry Kit (VS-0525-XY7407)
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- Species Reactivity: Human, Mouse, Rat, Goat, Rabbit
- Target: TNNI3
- Application: IHC
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- Anti-Human TNNI3 Immunohistochemistry Kit (VS-0525-XY7406)
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- Species Reactivity: Human
- Target: TNNI3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).