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EGFR & IGFR

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Anti-EGFR & IGFR Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
EGFR & IGFR
Related Diseases
Bladder Cancer Bladder Cancer
Non-small Cell Lung Cancer Non-small Cell Lung Cancer
Pancreatic Cancer Pancreatic Cancer
Hepatocellular Carcinoma Hepatocellular Carcinoma
Cushing Syndrome Cushing Syndrome
Related Signaling Pathways
JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
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