EGFR & IGFR

Anti-EGFR & IGFR Products

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Anti-Human EGFR Recombinant Antibody (Cetuximab) (TAB-003)
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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Anti-Human EGFR Recombinant Antibody (Modotuximab) (TAB-H49)
- Derivation: Chimeric
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
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Mouse Anti-EGFR Recombinant Antibody (clone 7A7) (PABW-088)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
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Anti-Human EGFR Recombinant Antibody (Panitumumab) (TAB-020)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG2 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
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Anti-EGFR Recombinant Antibody (Nimotuzumab) (TAB-710)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
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Anti-EGFR Recombinant Antibody (Imgatuzumab) (TAB-753)
- Derivation: Humanized (from rat)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, WB
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Anti-Human EGFR Recombinant Antibody (TAB-119) (TAB-119)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, WB
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Anti-Human EGFR Recombinant Antibody (ABT-806) (TAB-228CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Application: WB, IHC
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Mouse Anti-EGFR Recombinant Antibody (TAB-271MZ) (TAB-271MZ)
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: FuncS
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Human Anti-EGFR Recombinant Antibody (TAB-272MZ) (TAB-272MZ)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: FuncS
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Human Anti-EGFR Recombinant Antibody (TAB-278MZ) (TAB-278MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, ELISA, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-279MZ) (TAB-279MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, ELISA, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-282MZ) (TAB-282MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, FuncS, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-0225CL) (TAB-0225CL)
- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (Mouse/Human) IgG1
- Application: Block, Inhib, FuncS, Apop, In vivo
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-0225CL-S(P)) (TAB-0225CL-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: Block, Inhib, FuncS, Apop, In vivo
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Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-0225CL-F(E)) (TAB-0225CL-F(E))
- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (Mouse/Human) Fab
- Application: Block, Inhib, FuncS, Apop, In vivo
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-270MZ-S(P)) (TAB-270MZ-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody (PABL-080) (PABL-080)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB, FuncS
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Human Anti-EGFR Recombinant Antibody (TAB-274MZ) (TAB-274MZ)
- Species Reactivity: Human
- Type: Humanized IgG
- Application: FC
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-274MZ-S(P)) (TAB-274MZ-S(P))
- Species Reactivity: Human
- Type: Humanized scFv
- Application: FC
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Human Anti-EGFR Recombinant Antibody (TAB-283MZ) (TAB-283MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, FuncS, Inhib
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-278MZ-S(P)) (TAB-278MZ-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB
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Human Anti-EGFR Recombinant Antibody (TAB-284MZ) (TAB-284MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody (TAB-287MZ) (TAB-287MZ)
- Species Reactivity: Human
- Type: Human IgG1
- Application: ADCC assay
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Human Anti-EGFR Recombinant Antibody (TAB-288MZ) (TAB-288MZ)
- Species Reactivity: Human
- Type: Human IgG1
- Application: ADCC assay
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Human Anti-EGFR Recombinant Antibody (TAB-289MZ) (TAB-289MZ)
- Species Reactivity: Human
- Type: Human IgG1
- Application: ADCC assay
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Human Anti-EGFR Recombinant Antibody (TAB-290MZ) (TAB-290MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Block, Cyt, ELISA, FC, FuncS, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-291MZ) (TAB-291MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Block, Cyt, ELISA, FC, FuncS, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-292MZ) (TAB-292MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: In vitro binding assay
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Human Anti-EGFR Recombinant Antibody (TAB-293MZ) (TAB-293MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: In vitro binding assay
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Human Anti-EGFR Recombinant Antibody (TAB-294MZ) (TAB-294MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: In vitro binding assay
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Human Anti-EGFR Recombinant Antibody (TAB-295MZ) (TAB-295MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: In vitro binding assay
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Human Anti-EGFR Recombinant Antibody (TAB-296MZ) (TAB-296MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: In vitro binding assay
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Anti-Human EGFR Recombinant Antibody (H225) (TAB-297MZ)
- Type: Humanized antibody
- Application: ELISA, WB
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Anti-Human EGFR Recombinant Antibody (Hu225) (TAB-298MZ)
- Type: Humanized antibody
- Application: ELISA, WB
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Human Anti-EGFR Recombinant Antibody (TAB-299MZ) (TAB-299MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: FC, FuncS, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-300MZ) (TAB-300MZ)
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody (clone C225) (PABL-462)
- Species Reactivity: Human
- Type: Human IgG
- Application: FC
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Mouse Anti-EGFR Recombinant Antibody (PABW-171) (PABW-171)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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Anti-Human EGFR Recombinant Antibody (TAB-040) (TAB-040)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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Anti-EGFR/HER1 Recombinant Antibody (TAB-750) (TAB-750)
- Derivation: Chimeric (Human/Mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, WB
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Mouse Anti-EGFR Recombinant Antibody (clone 42C11) (MOB-1078z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, IF, IHC, FuncS
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Anti-Human EGFR Recombinant Antibody (Futuximab) (TAB-H35)
- Derivation: Chimeric (human/mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, WB, Inhib
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Anti-Human EGFR Recombinant Antibody (Matuzumab) (TAB-165)
- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG1
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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Afuco™ Anti-Human EGFR ADCC Recombinant Antibody (ABT-806), ADCC Enhanced (AFC-216CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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Human Anti-EGFR Recombinant Antibody (TAB-302MZ) (TAB-302MZ)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1
- Application: ELISA
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-272MZ-S(P)) (TAB-272MZ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-279MZ-S(P)) (TAB-279MZ-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-282MZ-S(P)) (TAB-282MZ-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-283MZ-S(P)) (TAB-283MZ-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-284MZ-S(P)) (TAB-284MZ-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-281MZ-S(P)) (TAB-281MZ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, IF, IHC
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-273MZ-S(P)) (TAB-273MZ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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Mouse Anti-EGFR Recombinant Antibody (TAB-303MZ) (TAB-303MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, Inhib
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Mouse Anti-EGFR Recombinant Antibody (TAB-304MZ) (TAB-304MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, Inhib
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Mouse Anti-EGFR Recombinant Antibody (TAB-305MZ) (TAB-305MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, Inhib
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Mouse Anti-EGFR Recombinant Antibody (TAB-306MZ) (TAB-306MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, Inhib
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Recombinant Anti-Mouse Egfr VHH Single Domain Antibody (NABG-056)
- Species Reactivity: Mouse
- Type: Llama VHH
- Application: ELISA, IHC, FC, FuncS
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Human Anti-EGFR Recombinant Antibody (clone C225); Fab Fragment (PFBL-459)
- Species Reactivity: Human
- Type: Human Fab
- Application: FC
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Human Anti-EGFR Recombinant Antibody (clone h-R3); Fab Fragment (PFBL-460)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB, FuncS
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (PFBW-171) (PFBW-171)
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB
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Human Anti-EGFR Recombinant Antibody (clone C225); scFv Fragment (PSBL-459)
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
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Mouse Anti-EGFR Recombinant Antibody (TAB-0564CL) (TAB-0564CL)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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Mouse Anti-EGFR Recombinant Antibody (TAB-0565CL) (TAB-0565CL)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody (clone h-R3); scFv Fragment (PSBL-460)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, WB, FuncS
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10-FnIII scaffold protein anti-Human EGFR (SFN-L003)
- Scaffold Name: 10-FnIII
- Target: EGFR
- Species Reactivity: Human
- Derivation: Phage display
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Z-domain of protein A scaffold protein anti-Human EGFR (SZA-L219)
- Scaffold Name: Z-domain of protein A
- Target: EGFR
- Species Reactivity: Human
- Derivation: Phage display
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Anti-EGFR Antibody-Cytokine Fusion Protein, IgG-IL2 (ACFP-SH155)
- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: IgG1-IL2
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Mouse Anti-EGFR Recombinant Antibody (TAB-301MZ) (TAB-301MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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Mouse Anti-EGFR Recombinant Antibody (TAB-285MZ) (TAB-285MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FuncS
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Mouse Anti-EGFR Recombinant Antibody (TAB-286MZ) (TAB-286MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FuncS
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-275MZ-S(P)) (TAB-275MZ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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Anti-Human EGFR Recombinant Antibody scFv Fragment (LA1) (TAB-276MZ-S(P))
- Application: MTT assay
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Anti-Human EGFR Recombinant Antibody scFv Fragment (LA22) (TAB-277MZ-S(P))
- Application: MTT assay
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Mouse Anti-EGFR Recombinant Antibody (TAB-275MZ) (TAB-275MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: Cyt, FuncS, Inhib
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Anti-Human EGFR Recombinant Antibody (LA1) (TAB-276MZ)
- Application: Cyt, FuncS
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Anti-Human EGFR Recombinant Antibody (LA22) (TAB-277MZ)
- Application: Cyt, FuncS
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Human Anti-EGFR Recombinant Antibody; Fab Fragment (PFBL-080) (PFBL-080)
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FuncS
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Recombinant Anti-Human EGFR VHH Single Domain Antibody (PNBL-016) (PNBL-016)
- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, ELISA
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Recombinant Anti-Human EGFR VHH Single Domain Antibody (PNBL-017) (PNBL-017)
- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: FuncS, ELISA, IF
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Recombinant Anti-Human EGFR VHH Single Domain Antibody (PNBL-018) (PNBL-018)
- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: FuncS, SPR
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-271MZ-S(P)) (TAB-271MZ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
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Mouse Anti-EGFR Recombinant Antibody (TAB-281MZ) (TAB-281MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IF, IHC
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Mouse Anti-EGFR Recombinant Antibody (TAB-273MZ) (TAB-273MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, IHC, IP, Inhib
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Anti-EGFR (ABT-806)-Mc-MMAE ADC (ABT-414) (ADC-L001)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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Recombinant Anti-EGFR × Anti-IGFR Bispecific Antibody (Tandem Diabody) (TAND-L052)
- Targets: EGFR & IGFR
- Type: Tandem Diabody
- Application: FuncS, Promising therapeutic agent
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Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-EGFR-mc-MMAF ADC (ADC-039CL)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (clone Bat0206)-S-3AA-MDC ADC (ADC-157CL)
- Target: EGFR
- Linker: S-3AA
- Drug: MDC (maytansinol)
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Anti-EGFR (clone Antibody 1)-MC-MMAF ADC (ADC-059CL)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (clone Bat0206)-SMCC-MDC ADC (ADC-158CL)
- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: MDC (maytansinol)
Compare

Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
- Target: epidermal growth factor receptor (EGFR)
- Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MODO (monomethyldolastatin)
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Anti-EGFR-Mal-dPEG4-NHS-DM1 ADC (ADC-107LCT)
- Target: EGFR
- Linker: Mal-dPEG4-NHS
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-EGFR (MAb806)-Mc-MMAF ADC (ADC-109LCT)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
- Target: EGFR variant III
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
- Target: EGFRvIII
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
- Target: EGFR
- Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
- Drug: doxorubicin
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For Research Use Only. Not For Clinical Use.

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

EGFR: Functions as a receptor tyrosine kinase controlling cell growth and differentiation. It activates multiple signaling cascades upon ligand binding. The protein is widely expressed in epithelial tissues. Mutations drive oncogenesis.

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Related Signaling Pathways

JAK-STAT Signaling Pathway