Anti-TP53 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs has established a name as the premiere provider of cutting-edge reagents for cancer research and development. Our elite range of anti-TP53 recombinant antibodies are one of our most popular products, and for good reason. Tumor Protein p53, also known as p53, is the most significant tumor suppressor in the human genome. Dubbed the "guardian of the genome," p53 is at the center of some of the most important and fundamental research on how cancer develops, and how it can be stopped. No anti-cancer drug is complete without testing on its functionality. For this reason, our high-quality recombinant antibodies are the backbone of cancer research, used for studying its activity, determining its mutational status, and quantifying its response to DNA damage and chemotherapy.

TP53: The Guardian of the Genome

Tumor Protein p53 (TP53) is a transcription factor that functions as a convergence point in a complex network of cellular stress response pathways. In the absence of stress, p53 is kept at extremely low levels by its negative regulator MDM2, which ubiquitinates the protein and targets it for degradation. However, under conditions of cellular stress, such as DNA damage or oncogene activation, p53 is rapidly stabilized and activated. The stabilized p53 protein then moves to the nucleus, where it activates a transcriptional program that generally has one of three possible outcomes: a reversible cell cycle arrest to allow time for DNA repair, irreversible cell cycle arrest (senescence), or programmed cell death (apoptosis). Loss-of-function mutations in TP53 are the most common genetic alteration found in human cancer, present in over 50% of all human tumors.

Alternative Names

Tumor Protein P53; Phosphoprotein P53; Antigen NY-CO-13; P53; Transformation-Related Protein 53; Cellular Tumor Antigen P53; Mutant Tumor Protein 53; Li-Fraumeni Syndrome

Background

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants.

Anti-TP53 rAb Products

Creative Biolabs' recombinant antibodies against TP53 are the gold standard in cancer research. We offer a full range of the most useful reagents including antibodies that detect wild-type p53, antibodies that detect common mutant conformations specifically, and an extensive collection of phospho-specific antibodies that allow you to follow activation of the protein at specific sites (such as Ser15). Optimized for IHC, Western Blot, and ChIP, our recombinant antibodies (rAbs) represent the most reliable choice for your research.

Table 1. Featured anti-TP53 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs' commitment to quality is unwavering. We have established an exacting quality assurance process to oversee the production of our anti-TP53 recombinant antibodies. Every lot of antibodies is rigorously tested for purity, specificity, and reproducible performance in validated cell models, so that you can count on receiving the highest quality reagent for your most important experiments.

Customer Reviews

rAb Production

Creative Biolabs is proud to use some of the most advanced production technologies available to accelerate progress in cancer research. Our anti-TP53 recombinant antibodies, including our extensive panel of modification-specific reagents, are developed to the highest standards to give you the most specific and sensitive reagents possible.

Featured Anti-TP53 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-TP53 recombinant antibody production.

Fig.4 Gram-scale anti-TP53 recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to providing the research community with flexible and innovative research tools. Our anti-TP53 recombinant antibodies are available in a wide variety of formats and conjugates to support a broad range of experimental applications in studying this essential tumor suppressor.

Fig.5 Full-length anti-TP53 recombinant antibody production and modalities.

Progress in your cancer research starts with Creative Biolabs' premium anti-TP53 recombinant antibodies. Our extensive portfolio is uniquely characterized by its unrivaled specificity and our rigorous validation, ensuring that you have the best possible tools for your fundamental research and drug discovery projects. Let our expertise be an asset to your important work. Contact our specialists today.