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TRBC1
TRBC1 (T Cell Receptor Beta Constant 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Translocation of ZAP-70 to Immunological synapse. An important paralog of this gene is TRBC2.
Protein class
T-cell receptor genes
Predicted location
Membrane
Single cell type specificity
Group enriched (NK-cells, T-cells, dendritic cells)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Cell line enriched (JURKAT)
Interaction
Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.
More Types Infomation
- Human Anti-TRBC1 Antibody (clone IARC307), mRNA (FAMAB-1510CQ-mRNA)
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- Species Reactivity: Human
- Human Anti-TRBC1 Recombinant Antibody (clone IARC307) (FAMAB-1510CQ)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, FC, IF
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For Research Use Only. Not For Clinical Use.