TRPC6

Recombinant Antibody Products

Anti-TRPC6 Recombinant Antibody Products

Chicken Anti-TRPC6 Polyclonal IgY (BRD-0737MZ)
- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters, Voltage-gated ion channels

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Inhibitory neurons, Smooth muscle cells, Excitatory neurons, Microglial cells, Club cells)

Immune cell specificity

Immune cell enriched (eosinophil)

Cell line specificity

Cell line enhanced (A549, ASC diff, BJ hTERT+, HEL, RPTEC TERT1)

Interaction

Homodimer; forms channel complex (PubMed:26892346). Interacts with MX1 and RNF24 (PubMed:15757897, PubMed:17850865).

Molecular function

Calcium channel, Ion channel

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