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TSSK6
Anti-TSSK6 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BEWO, CACO-2)
Interaction
Interacts with HSP90; this interaction stabilizes and activates TSSK6 (By similarity). Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity.
Molecular function
Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
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