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TXNRD1

Anti-TXNRD1 Products
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- Species Reactivity: Human
- Application: ELISA, FC, ICC/IF, IP, WB
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, IF, IP
- Rabbit Anti-TXNRD1 Recombinant Antibody (VS3-WK1023) (VS3-WK1023)
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC
- Rabbit Anti-TXNRD1 Recombinant Antibody (clone JA11-32) (MRO-1542-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
- Anti-TXNRD1 Immunohistochemistry Kit (VS-0325-XY2402)
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- Species Reactivity: Human, Mouse, Rat
- Target: TXNRD1
- Application: IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC, IP, FC
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.

Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Prostatic glandular cells, Urothelial cells, Basal prostatic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (fHDF/TERT166)
Interaction
Homodimer (PubMed:17512005, PubMed:8577704). Interacts with HERC5. [Isoform 4]: Interacts with ESR1 and ESR2.
Molecular function
Oxidoreductase
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