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UACA
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For Research Use Only. Not For Clinical Use.
Background
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, Microglial cells, Endothelial cells, Cardiomyocytes)
Immune cell specificity
Immune cell enhanced (intermediate monocyte)
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+)
Interaction
Component of the apoptosome complex, composed of APAF1, pro-caspase-9 and UACA. In the complex, it probably interacts directly with APAF1. Interacts with LGALS3, ARF6 and ACTB. Interacts with RAB39A (By similarity).
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