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UBA7

Anti-UBA7 Products
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, FC
- Mouse Anti-UBA7 Recombinant Antibody (clone 5B10) (VS3-XY1572)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
- Anti-Mouse UBA7 Immunohistochemistry Kit (VS-0525-XY7685)
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- Species Reactivity: Human, Mouse, Rat
- Target: UBA7
- Application: IHC
- Anti-UBA7 Immunohistochemistry Kit (VS-0525-XY7684)
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- Species Reactivity: Human
- Target: UBA7
- Application: IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IF, IP, WB
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For Research Use Only. Not For Clinical Use.
Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
Protein class
Metabolic proteins, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (granulocytes, Gastric mucus-secreting cells, Proximal enterocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, HEL, HMC-1)
Interaction
Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.
Molecular function
Ligase
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