+ Filter
Loading...
VPREB1
Anti-VPREB1 Recombinant Antibody Products
CompareCan't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants.
Protein class
CD markers
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells)
Immune cell specificity
Group enriched (memory B-cell, naive B-cell)
Cell line specificity
Group enriched (Daudi, MOLT-4, RPMI-8226)
Interaction
Interacts with IGLL1 (PubMed:17431183). Interacts with SYNV1/HRD1 (via N-terminus); this interaction leads to increased VPREB1 ubiquitination and degradation in pre-B cells, possibly through a lysosomal, not proteasomal, pathway (By similarity).
More Types Infomation