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VRK2
Anti-VRK2 Recombinant Antibody Products
- Anti-VRK2 Immunohistochemistry Kit (VS-0325-XY2477)
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- Species Reactivity: Human, Mouse, Rat
- Target: VRK2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (Oligodendrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Isoform 1 interacts with MAP3K7, MAP2K7, MAP2K1 and KSR1 (PubMed:20679487, PubMed:17709393, PubMed:18286207). Isoform 1 and isoform 2 interact with RAN and MAPK8IP1 (PubMed:18286207, PubMed:18617507). (Microbial infection) Isoform 1 interacts with Epstein-Barr virus BHRF1; this interaction is involved in protecting cells from apoptosis. (Microbial infection) Isoform 1 interacts with vaccinia protein B12.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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