WWOX

Antibody Magnetic Beads AbPlus Formats

Anti-WWOX Recombinant Antibody Products

AbPlus™ Anti-WWOX Magnetic Beads (VS-0724-YC1180) (VS-0724-YC1180)
- Target: WWOX
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Protein class

Disease related genes, Human disease related genes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Group enriched (Astrocytes, Oligodendrocyte precursor cells, Oligodendrocytes, Inhibitory neurons, Microglial cells, Excitatory neurons)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (MCF7)

Interaction

Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207.

Molecular function

Oxidoreductase

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