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Xcr1

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Protein class

G-protein coupled receptors, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enriched (Langerhans cells)

Immune cell specificity

Immune cell enriched (myeloid DC)

Cell line specificity

Cell line enhanced (HEL, Karpas-707, RT4, U-266/84, U-87 MG)

Molecular function

G-protein coupled receptor, Receptor, Transducer

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