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HIST2H2BF
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For Research Use Only. Not For Clinical Use.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and is found in a histone cluster on chromosome 1.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Hofbauer cells, Syncytiotrophoblasts, Cardiomyocytes, Cytotrophoblasts, Extravillous trophoblasts, Fibroblasts)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enriched (U-266/70)
Interaction
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Molecular function
DNA-binding
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