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IL1RN
Loading...Anti-IL1RN Products
- Mouse Anti-IL1RN Recombinant Antibody (clone CBL417) (NEUT-1305CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, Neut
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- Anti-IL1RN Immunohistochemistry Kit (VS-0525-XY3509)
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- Species Reactivity: Human
- Target: IL1RN
- Application: IHC
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- Anti-Mouse IL1RN Immunohistochemistry Kit (VS-0525-XY3510)
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- Species Reactivity: Human, Mouse, Rat
- Target: IL1RN
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Squamous epithelial cells, Urothelial cells, Suprabasal keratinocytes, Hofbauer cells, Langerhans cells, Basal keratinocytes)
Immune cell specificity
Group enriched (neutrophil, classical monocyte, myeloid DC)
Cell line specificity
Cell line enhanced (A-431, HaCaT, RT4, THP-1)
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