Anti-EpCAM Antibody-Cytokine Fusion Protein, scFv (HuKS)-IL12 (CAT#: ACFP-SH032)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM scFv to IL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of IL12. This fusion protein is directed against EpCAM and enhances the uptake of immunocytokine into tumors. This immunocytokine was designed for treating solid tumor.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Target
  • EpCAM
  • Molecule Class
  • scFv-IL12
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • HuKS
  • Related Disease
  • Solid tumors
  • Cytokine 1
  • IL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component; chromosome 4; surface marker (35kD glycoprotein)

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Humanized Antibody

CAT Product Name Application Type
TAB-213 Humanized Anti-EPCAM Recombinant Antibody (clone Tucotuzumab) WB, Neut, ELISA, IF, IP, FuncS, FC Humanized (from mouse) IgG1
TAB-112-F(E) Anti-Human EpCAM Recombinant Antibody Fab Fragment, 17-1A (Citatuzumab Bogatox) Neut, ELISA, IF, IP, FuncS, FC, ICC Fab - G1 - kappa
TAB-374MZ Anti-Human EPCAM Recombinant Antibody (h12H8B) FC, ELISA Humanized antibody
TAB-375MZ Anti-Human EPCAM Recombinant Antibody (h12H8C) FuncS, Inhib Humanized antibody
TAB-376MZ Anti-Human EPCAM Recombinant Antibody (h2D11B) Cyt, Inhib Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-L013E anti-EPCAM immunotoxin MOC31 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L013D anti-EPCAM immunotoxin MOC31 (IgG)-DT Cytotoxicity assay, Functional assay
AGTO-L013G anti-EPCAM immunotoxin MOC31 (IgG)-Gel Cytotoxicity assay, Functional assay
AGTO-L013R anti-EPCAM immunotoxin MOC31 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L013O anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin Cytotoxicity assay, Functional assay

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1163 Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) IHC-P, WB, ICC, ICC, IF Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-106 Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Adecatumumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut ADCC enhanced antibody
AFC-TAB-213 Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Tucotuzumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS ADCC enhanced antibody
AFC-TAB-701 Afuco™ Anti-EpCAM ADCC Recombinant Antibody (Edrecolomab), ADCC Enhanced ELISA, IP, FC, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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