Anti-EpCAM Antibody-Cytokine Fusion Protein, IgG-ala (huKS)-IL2 (N88R)
CAT#: ACFP-SH073
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG-ala to IL2 (N88R). It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of IL2 (N88R). This huKS-IL2 variant contains the same amino acid substitution at the junction between the Ig heavy chain constant region and mature huIL2 (K-A, created by the codon change AAA to GCC), and in addition it contains a substitution at position N88 in the sequence of mature huIL2 in favor of R (created by codon change aAT to aGG). This immunocytokine was designed for treating solid tumor.





Specifications
- Target
- EpCAM
- Molecule Class
- L Kappa; IgG4-ala-IL2 (N88R)
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- huKS
- Related Disease
- Solid tumors
- Cytokine 1
- IL2 (N88R)
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component; chromosome 4; surface marker (35kD glycoprotein)
- Gene ID
- 4072
- UniProt ID
- P16422
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Datasheet
MSDS
COA
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