This antibody strongly binds to both factors hIGF-I and hIGF-II and inhibit their functions. KM1468 does not merely recognaize an amino acid primary sequence of hIGF-I but recognizes three-dimensional structure of hIGF-I.
Figure 1 Intense peripheral staining with an anti-IGF-IR antibody is observed on the cell membrane of MCF-7 cells.
Sangai, T., Fujimoto, H., Miyamoto, S. I., Maeda, H., Nakamura, M., Ishii, G., ... & Ochiai, A. (2008). Roles of osteoclasts and bone-derived IGFs in the survival and growth of human breast cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice. Clinical & experimental metastasis, 25(4), 401-410.
Figure 2 Effects of combination therapy of KM1468 and DOX on the growth of bone tumors.
Control IgG (4W) represents the data of Protocol 2 and is shown again for reference. The tumor area at 8 weeks after the MCF-7 cell injection is about 3-fold larger than the area at 4 weeks after the injection, when control IgG alone is administered. The combination therapy of KM1468 and DOX significantly suppresses the growth of MCF-7 cells in HAB. Data represent means ± SE (Control IgG, n = 10; KM1468, n = 10; Control IgG + DOX, n = 6; KM1468 + DOX, n = 9)
Sangai, T., Fujimoto, H., Miyamoto, S. I., Maeda, H., Nakamura, M., Ishii, G., ... & Ochiai, A. (2008). Roles of osteoclasts and bone-derived IGFs in the survival and growth of human breast cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice. Clinical & experimental metastasis, 25(4), 401-410.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-005ZJ-S(P) | Anti-Human IGF I Recombinant Antibody scFv Fragment (KM1468) | ELISA, Inhib | |
TAB-005ZJ-F(E) | Anti-Human IGF I Recombinant Antibody Fab Fragment (KM1468) | ELISA, Inhib |
There are currently no Customer reviews or questions for TAB-005ZJ. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.