Products

Durvalumab (TAB-417CQ)

Recombinant monoclonal antibody to CD274. Durvalumab is a human monoclonal antibody that can be potentially used in the treatment of Cancers, non-small cell lung (NSCLC), Solid tumors, bladder, urothelial.      

  • Published Data
  • Datasheet
FuncS

Figure 1 Monalizumab and Durvalumab Unleash NK and CD8 + T Cell Function In Vitro.

NK cells were co-cultured with K562 or K562 cells expressing HLA-E in the presence or absence of monalizumab. The frequencies of CD107-positive NK cells are shown. Box and whiskers plot, with the means indicated by crosses. N = 8. The whiskers are drawn down to the 25th percentile minus 1.5 times IQR (interquartile range) and up to the 75th percentile plus 1.5 times IQR. Friedman analysis followed by Dunn's multiple comparisons test. **p = 0.006; ***p = 0.0001.

André, P., Denis, C., Soulas, C., Bourbon-Caillet, C., Lopez, J., Arnoux, T.,... & Rossi, B. (2018). Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells. Cell, 175(7), 1731-1743.


Specifications
Immunogen
The details of the immunogen for this antibody are not available.
Host
Human
Derivation
Human
Type
IgG1, κ
Specificity
Human CD274
Species Reactivity
Human
Applications
ELISA, IHC, FC, IP, IF, Inhib, FuncS
Conjugate
Unconjugated
Trade name
Imfinzi
CAS NO.
1428935-60-7
Generic Name
Durvalumab
UNII
28X28X9OKV
Related Disease
Cancers, non-small cell lung (NSCLC), Solid tumors, bladder, urothelial
Applications
Application Notes
The CD274 antibody has been reported in applications of ELISA, IHC, FC, IP, IF, Inhib, FuncS.
Target
Alternative Names
Programmed cell death 1 ligand 1; B7H1; B7-H1; PDL1; PD-L1; PDCD1L1; B7 homolog 1; B7 homologue 1
Entrez Gene ID
29126
UniProt ID
Q9NZQ7

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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