Anti-Human CD274 Recombinant Antibody (Durvalumab) (CAT#: TAB-417CQ)

Recombinant monoclonal antibody to CD274. Durvalumab is a human monoclonal antibody that can be potentially used in the treatment of Cancers, non-small cell lung (NSCLC), Solid tumors, bladder, urothelial.

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FuncS

Figure 1 Monalizumab and Durvalumab Unleash NK and CD8 + T Cell Function In Vitro.

Figure 1 Monalizumab and Durvalumab Unleash NK and CD8 + T Cell Function In Vitro.

NK cells were co-cultured with K562 or K562 cells expressing HLA-E in the presence or absence of monalizumab. The frequencies of CD107-positive NK cells are shown. Box and whiskers plot, with the means indicated by crosses. N = 8. The whiskers are drawn down to the 25th percentile minus 1.5 times IQR (interquartile range) and up to the 75th percentile plus 1.5 times IQR. Friedman analysis followed by Dunn's multiple comparisons test. **p = 0.006; ***p = 0.0001.

André, P., Denis, C., Soulas, C., Bourbon-Caillet, C., Lopez, J., Arnoux, T.,... & Rossi, B. (2018). Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells. Cell, 175(7), 1731-1743.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG1, κ
  • Specificity
  • Human CD274
  • Species Reactivity
  • Human
  • Applications
  • ELISA, IHC, FC, IP, IF, Inhib, FuncS
  • Conjugate
  • Unconjugated
  • Trade name
  • Imfinzi
  • CAS
  • 1428935-60-7
  • Generic Name
  • Durvalumab
  • UNII
  • 28X28X9OKV
  • Related Disease
  • Cancers, non-small cell lung (NSCLC), Solid tumors, bladder, urothelial

Product Property

  • Purity
  • > 95% as determined by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Applications

  • Application Notes
  • The CD274 antibody has been reported in applications of ELISA, IHC, FC, IP, IF, Inhib, FuncS.

Target

  • Alternative Names
  • Programmed cell death 1 ligand 1; B7H1; B7-H1; PDL1; PD-L1; PDCD1L1; B7 homolog 1; B7 homologue 1

Related Resources

  • Biosimilar Overview
  • Citations
Please refer to Durvalumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Durvalumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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See other products for "Durvalumab"

Afuco™ Anti-CD274 ADCC Recombinant Antibody (Durvalumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD274. Durvalumab is a human monoclonal antibody that can be potentially used in the treatment of Cancers, non-small cell lung (NSCLC), Solid tumors, bladder, urothelial.

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Customer Reviews and Q&As

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  • Ideal for Durvalumab Studies
    The Durvalumab has been excellent for our PD-L1 studies. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.
  • Effective in Immunoassays
    We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for PD-L1 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.
  • Consistent and High-Quality
    This antibody has proven to be consistent and high-quality in our assays. The reproducible results and strong affinity for PD-L1 have significantly improved our experiments, making it a crucial part of our research toolkit. The consistent performance has greatly enhanced our data quality.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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