Omalizumab
CAT#: TP-097CL
A recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E (IgE). omalizumab is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1245/3618_A_9_3.jpg
Normal Tissue
Figure 2 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1245/3618_A_9_4.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1245/3618_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1245/3618_A_5_6.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (Karpas-707, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000211896-IGHG1
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Specifications
- Type
- Biotech
- Trade name
- omalizumab
- UNII
- 2P471X1Z11
Target
- Function
- Humanized mAb that inhibits ige binding to the high-affinity ige receptor on mast cells and basophils, decreasing activation of these cells and release of inflammatory mediators
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Excellent for Allergy Studies
Omalizumab has revolutionized our allergy research methodologies. Its high specificity for IgE allowed us to closely examine immune responses without interference. The clarity it brought to our IgE receptor studies was unparalleled, making it a staple in our lab.
Exceptional Quality and Precision
The precision afforded by Omalizumab in blocking IgE was impressive. Its application in our bioassays resulted in reproducible data that furthered our exploration into immune modulating treatments.
Consistent and Dependable Results
With Omalizumab, we consistently obtained dependable results in our IgE-focused assays. Its specificity ensured minimized cross-reactivity, essential for accurate data interpretation.
Helps Map Signaling Pathways
It became a cornerstone in our studies mapping IgE signaling pathways. Omalizumab's use allowed us to chart detailed maps of allergic response mechanisms, offering insights into novel drug discovery.
Perfect for IgE Modulation Studies
Omalizumab's blocking action on IgE has been perfect for our studies on immune modulation. It helped reveal how IgE interactions affect broader immune responses, a critical aspect of our research.
Q&As
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What is the primary target of Omalizumab?
A: Omalizumab targets human immunoglobulin E (IgE), a key player in allergic reactions. By binding to IgE, it prevents it from attaching to its receptors on immune cells, thereby dampening the allergic response.
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What are potential uses for Omalizumab in laboratory settings?
A: This antibody can be utilized to investigate mechanisms of allergic inflammation, perform binding studies, and in bioassays to test the efficacy of novel therapies targeting IgE-related pathways.
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Can Omalizumab be used as a control in IgE-related assays?
A: Yes, it can function as a control to evaluate the neutralization or binding capacity of other therapeutic candidates targeting IgE.
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How does Omalizumab help in studying immune cell interactions?
A: By blocking IgE, it aids in dissecting the roles of mast cells and basophils in allergic and autoimmune responses, contributing to a better understanding of cell signaling and immune regulation.
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What is the role of Omalizumab in signaling pathway analysis?
A: It serves as a critical tool in dissecting IgE-mediated signal transduction and understanding the broader implications of IgE receptor blockade on immune cell functions.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TP-097CL, RRID: AB_3112053)
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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