Recombinant Anti-Human MALAT1 Antibody (CAT#: MOB-4044z)
Recombinant Mouse Antibody is capable of binding to Human MALAT1, expressed in Chinese Hamster Ovary cells(CHO).
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Immunogen
- Human metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native Human metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
- Species Reactivity
- Human
- Applications
- Can be useful in applications such as: Western blot; Flow Cytometry; Functional Study
Product Property
- Purity
- Purity>95% by SDS-PAGE
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Target
- Alternative Names
- MALAT1; Hepcarcin; PRO1073; MascRNA; Nuclear Paraspeckle Assembly Transcript 2 (Non-Protein Coding); Metastasis Associated In Lung Adenocarcinoma Transcript 1; Non-Protein Coding RNA 47; PRO2853; Nuclear Enriched Abundant Transcript 2; NEAT2; Metastasis A
- Gene ID
- 378938
- UniProt ID
- Q9UHZ2
Related Resources
Chang, Hang-Lung, et al. "Targeting the epigenetic non-coding RNA MALAT1/Wnt signaling axis as a therapeutic approach to suppress stemness and metastasis in hepatocellular carcinoma." Cells 9.4 (2020): 1020. https://doi.org/10.3390/cells9041020
This research investigates the role of MALAT1, a long non-coding RNA, in hepatocellular carcinoma (HCC) development and progression. The study demonstrates that MALAT1 is aberrantly overexpressed in HCC tissues and cell lines compared to normal liver tissues, with expression levels correlating with poor cellular differentiation and disease progression. Through shRNA-mediated silencing of MALAT1, the researchers showed that MALAT1 interacts directly with β-catenin and modulates the Wnt/β-catenin signaling pathway, thereby promoting cancer stemness characteristics. MALAT1 silencing reduced the CD133highCD90high HCC stem cell population, suppressed tumorsphere formation capacity, inhibited invasion and metastasis, and significantly reduced tumor growth in xenograft mouse models.
Creative Biolabs provided the recombinant antibody against MALAT1 (CAT#: MOB-4044z) that was crucial for detecting MALAT1 expression in HCC tissues using immunohistochemistry and RNAscope techniques. This antibody enabled the researchers to establish the correlation between MALAT1 expression levels and HCC differentiation status, which was fundamental to understanding MALAT1's clinical significance as a potential biomarker. The ability to accurately visualize MALAT1 distribution in different cellular contexts strengthened the study's findings regarding MALAT1's role in promoting stemness and metastasis in HCC through the Wnt/β-catenin signaling axis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Antibody Products
ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4044z-F(E) | Recombinant Anti-Human MALAT1 Antibody Fab Fragment | Neut, IF, FuncS | Fab |
Customer Reviews and Q&As
Customer Review
Q&As
Essential for RNA Research
The Anti-Human MALAT1 Antibody has proven essential in our RNA research laboratory. Its specificity for MALAT1 enhances our ability to study non-coding RNA interactions within the cell nucleus, providing invaluable insights into transcription regulation mechanisms.
Reliable Sensitivity and Specificity
This antibody offers outstanding sensitivity and specificity, crucial for our Western blot analyses. It reliably detects MALAT1, allowing us to quantify and study RNA in our cancer biology research effectively.
Ideal for Flow Cytometry
We've utilized this antibody in flow cytometry to explore RNA within cellular contexts. Its conjugation flexibility and consistency ensure detailed profiling of MALAT1, significantly advancing our understanding of its role in cell biology.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# MOB-4044z, RRID: AB_3111504)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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