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    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

    Human Anti-TNF (clone BPC1500) scFv-Fc Chimera

    CAT#: VS-0125-FY32

    This product is an innovative bispecific tandem single-chain variable fragment (scFv)-Fc fusion protein that combines specificity for the synaptic membrane with powerful activity against TNFα. This design enables precise targeting of inflammatory sites in rheumatoid arthritis, achieving significant targeted effects and effectively interrupting pathological processes. By enhancing local detoxification capabilities, the product aims to minimize damage to surrounding healthy tissues, thereby enhancing efficacy and reducing side effects.

    Gene Expression
    ❮
    Figure 1 Tonsil Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
    ❯

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Species Reactivity
    • Human
    • Clone
    • BPC1500
    • Applications
    • ELISA, Neutralization

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Stabilizer
    • No Stabilizers
    • Sterility
    • 0.2 μM filtered
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • The function of this scFv-Fc fusion protein is to possess both specific binding capacity to the synaptic membrane and neutralization ability against TNFα. Through this combination, the goal is to directly deliver anti-TNF effects at the site of inflammation in the joints, while reducing systemic TNF binding activity, potentially decreasing systemic side effects and enhancing therapeutic efficacy.

    Target

    • Alternative Names
    • Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2; Cachectin; TNF-Alpha; TNFSF2; TNF-A; TNFA; Tumor Necrosis Factor (TNF Superfamily, Member 2); Tumor Necrosis Factor Ligand 1F
    • Sequence Similarities
    • Belongs to the tumor necrosis factor family.
    • Cellular Localization
    • Cell membrane, Membrane, Secreted
    • Post Translation Modifications
    • The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
      The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
      O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
      Tumor necrosis factor, soluble form: The soluble form is demyristoylated at Lys-19 and Lys-20 by SIRT6, promoting its secretion.
    • Function
    • Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective.
      Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line.
      Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity).
      Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
      The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
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    Related Diseases

    Asthma Asthma
    Inflammatory Bowel Diseases Inflammatory Bowel Diseases

    Related Signaling Pathways

    TNF Signaling Pathway TNF Signaling Pathway

    Downloadable Resources

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - VS-0125-FY32.pdf

    MSDS

    MSDS - VS-0125-FY32.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

    Secondary Antibody

    • CAT
    • Product Name

    Isotype Control

    • CAT
    • Product Name

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