Recombinant Anti-Human TNF Antibody (Fc glycosylation) (CAT#: Gly-100LC)
This product is a chimeric (mouse/human) monoclonal antibody with glycoslyated site in Fc region. The antibody CNTO148 with reduced anti-drug immune response specifically binds TNFα and can be potentially used in the treatment of Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
Glyco-engineering
- Glycosylation site
- Fc region
- Glycosylation Type
- N-glycosylation
- Activity
- Reduced anti-drug immune response
Specifications
- Target
- TNFα (Tumor necrosis factor alpha)
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Clone
- CNTO148
- Expression Host
- YB2/0
- Applications
- ELISA
Target
- Alternative Names
- TNF; DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor
- Related Disease
- Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis
- Gene ID
- 7124
- UniProt ID
- P01375
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Human Antibodies
Chimeric Antibodies
Rat Antibodies
Humanized Antibodies
IgM Antibodies
Mouse Antibodies
Single Domain Antibodies
Fc Glycosylation Antibodies
Non-hyper Galactosylated Antibodies
Sialylated IgG Glycan
Hyper-galactosylated Antibodies
Chicken IgY Antibodies
Blocking Antibodies
Neutralizing Antibodies
Rabbit Monoclonal Antibodies
Fab Antibodies
IgG Antibodies
ScFv Antibodies
ADCC Enhanced Antibodies
Antibody Magnetic Beads
ScFv-Fc Chimeras
FC Reagents & Kits
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010 | Anti-Human TNF Recombinant Antibody (TAB-010) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG1, κ |
| TAB-119CQ-S(P) | Human Anti-TNF Recombinant Antibody; scFv Fragment (TAB-119CQ-S(P)) | ELISA, BL | Human scFv |
| TAB-120CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-120CQ-S(P)) | ELISA, Neut | Human antibody |
| TAB-121CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-121CQ-S(P)) | ELISA, Neut | Human antibody |
| TAB-122CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-122CQ-S(P)) | ELISA, Neut | Human antibody |
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For Research Use Only. Not For Clinical Use.
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