Afuco™ Anti-TNF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-006)

Name: Afuco™ Anti-TNF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-006)
SKU: AFC-TAB-006
Rating: 5 (1 reviews)

CAT#: AFC-TAB-006

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human TNF. It is a monoclonal antibody against tumour necrosis factor alpha (TNF-α) used to treat autoimmune diseases.

Gene Expression

Normal Tissue Figure 1 Tonsil

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF

❮

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Specifications

Immunogen
rhTNF emulsified with complete Fraud`s adjuvant.

Host Species
Chimeric

Derivation
Chimeric (mouse/human)

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
IF, IP, Neut, FuncS, ELISA, FC

Conjugate
Unconjugated

Trade name
Remicade, Remsima, Inflectra

Generic Name
Infliximab

Related Disease
Ankylosing spondylitis (AS)

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
TNF; tumor necrosis factor; TNFA, tumor necrosis factor (TNF superfamily, member 2); DIF; TNF superfamily; member 2; TNF alpha; TNFSF2; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived

Gene ID
7124

UniProt ID
P01375

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Biosimilar Overview

Please refer to Infliximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Infliximab.

Related Diseases

Asthma

Inflammatory Bowel Diseases

Related Signaling Pathways

TNF Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-006.pdf

MSDS

MSDS - AFC-TAB-006.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Infliximab"

Anti-Human TNF Recombinant Antibody (Infliximab)
Recombinant monoclonal antibody to Human TNF. Infliximab (INN; trade name Remicade) is a monoclonal antibody against tumour necrosis factor alpha (TNF-α) used to treat autoimmune diseases.
Infliximab was approved for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis.

DrugMonitor™ Anti-Infliximab Antibody (VS-1224-YC603)
Infliximab is a chimeric monoclonal IgG1 antibody targeting tumor necrosis factor-alpha (TNF-α), composed of human constant (75%) and murine variable (25%) regions, approved for intravenous treatment of various inflammatory disorders. The DrugMonitor™ Anti-Infliximab Antibody (VS-1224-YC603) is an anti-drug antibody (ADA) against Infliximab. This drug-based antibody is raised in mice immunized with the Infliximab. The anti-Infliximab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Infliximab in samples.

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NEUT-2068CQ	Mouse Anti-Tnf Recombinant Antibody (clone TN3-19)	ELISA, Neut, FuncS	Mouse IgG
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HPAB-0589-WJ-S(P)	Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0589-WJ-S(P))	ELISA	Human scFv
HPAB-0590-WJ-S(P)	Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0590-WJ-S(P))	ELISA	Human scFv
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