Anti-Human TNF Therapeutic Single Domain Antibody (TAB-415CQ) (CAT#: TAB-415CQ)

Recombinant monoclonal antibody to TNF. This product is a single domain antibody that can be potentially used in the treatment of rheumatoid arthritis.

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ELISA

Figure 1 Illustrate results of binding assays and pharmacokinetics of a VL-VL dimer of the invention.

Figure 1 Illustrate results of binding assays and pharmacokinetics of a VL-VL dimer of the invention.

Illustrate relative binding and specificity of the dimer to TNF molecules of various species by ELISA

ELISA

Figure 2 Illustrate results of binding assays and pharmacokinetics of a VL-VL dimer of the invention.

Figure 2 Illustrate results of binding assays and pharmacokinetics of a VL-VL dimer of the invention.

Illustrate relative binding and specificity of the dimer to TNF molecules of various species by ELISA

Figure 3 Illustrate results of binding assays and pharmacokinetics of a VL-VL dimer of the invention.

Figure 3 Illustrate results of binding assays and pharmacokinetics of a VL-VL dimer of the invention.

Illustrates pharmacokinetics of VL-VL constructs (VL18-3L-VL11 and VL18-3L-VL11-PEP) tested by administration to Wistar female rats to determine the serum half-life thereof in vivo

FuncS

Figure 4 Illustrates results of an assay for neutralization of TNF-alpha dependent cytolytic activity using VL-VL dimers of the invention, which shows that the dimers protected L929 cells from TNF-induced cytotoxicity.

Figure 4 Illustrates results of an assay for neutralization of TNF-alpha dependent cytolytic activity using VL-VL dimers of the invention, which shows that the dimers protected L929 cells from TNF-induced cytotoxicity.

FuncS

Figure 5Illustrates therapeutic effect of VL-VL dimers of the invention in an established rat adjuvant-induced arthritis model (AIA) based on clinical assessment of four limbs.

Figure 5Illustrates therapeutic effect of VL-VL dimers of the invention in an established rat adjuvant-induced arthritis model (AIA) based on clinical assessment of four limbs.

FuncS

Figure 6 Illustrates therapeutic effect of VL-VL dimers of the invention in an established rat adjuvant-induced arthritis model (AIA) based on changes in hind ankle swellings.

Figure 6 Illustrates therapeutic effect of VL-VL dimers of the invention in an established rat adjuvant-induced arthritis model (AIA) based on changes in hind ankle swellings.


Specifications

  • Host Species
  • Human
  • Type
  • Single domain antibody
  • Specificity
  • Human
  • Species Reactivity
  • Human, Rat
  • Clone
  • TAB-415CQ
  • Applications
  • ELISA, WB, Neut, FunS
  • Related Disease
  • Rheumatoid arthritis

Applications

  • Application Notes
  • The antibody was validated for ELISA, Western Blot, Neutralization, Functional Assay. For details, refer to Published Data.

Target

  • Alternative Names
  • TNF; DIF; TNFA; TNFSF2; TNF-alpha; TNLG1F; Tumor necrosis factor

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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