Human Anti-TNF Recombinant Antibody (clone A2) (CAT#: PABL-349)

Recombinant Human Antibody (A2) is capable of binding to TNFA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-TNFA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-TNFA mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 A graph showing neutralization of in vitro TNF cytotoxicity by murine A2. Control: murine IgG1 anti-lipid A mAb (8A1) with natural human TNF.

Figure 1 A graph showing neutralization of in vitro TNF cytotoxicity by murine A2. Control: murine IgG1 anti-lipid A mAb (8A1) with natural human TNF.

Figure 2 Graph showing that mAb A2 inhibits or neutralizes TNF produced by chimpanzee monocytes and rhTNFα.

Figure 2 Graph showing that mAb A2 inhibits or neutralizes TNF produced by chimpanzee monocytes and rhTNFα.

Figure 3 Graph showing results of a cross-blocking epitope ELISA with murine A2 (mA2) antibody.

Figure 3 Graph showing results of a cross-blocking epitope ELISA with murine A2 (mA2) antibody.


Specifications

  • Immunogen
  • Human tumor necrosis factor
  • Host Species
  • Human
  • Type
  • Human IgG
  • Specificity
  • Human TNF
  • Species Reactivity
  • Human
  • Clone
  • A2
  • Applications
  • WB, ELISA, FuncS

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The antibody was validated for Neutralization and ELISA. For details, refer to Published Data.

Target

  • Alternative Names
  • TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF; monocyte-derived; TNF; macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Single-domain Antibody

CAT Product Name Application Type
NABL-051 Recombinant Anti-human TNF VHH Single Domain Antibody WB, ELISA, IHC, FC, FuncS Llama VHH
TAB-412CQ Anti-Human TNF Therapeutic Single Domain Antibody (TAR1-5-19) ELISA, Inhib Single domain antibody
TAB-413CQ Anti-Human TNF Therapeutic Single Domain Antibody (VL18) ELISA, WB, Neut Single domain antibody
TAB-414CQ Anti-Human TNF Therapeutic Single Domain Antibody (VL11) ELISA, WB, Neut Single domain antibody
TAB-415CQ Anti-Human TNF Therapeutic Single Domain Antibody (VL18-3L-VL11) ELISA, WB, Neut, FunS Single domain antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-006 Anti-Human TNF Recombinant Antibody (Infliximab) IF, IP, Neut, FuncS, ELISA, FC, WB IgG1 - kappa
TAB-148CQ Anti-Human TNF Recombinant Antibody ELISA Chimeric antibody (mouse/human)
TAB-148CQ-S(P) Anti-Human TNF Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)
TAB-402CQ-S(P) Mouse Anti-TNF Recombinant Antibody; scFv Fragment (TAB-402CQ-S(P)) ELISA Mouse scFv
TAB-402CQ-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-402CQ-F(E)) ELISA Chimeric (mouse/human) Fab

Rat Antibody

CAT Product Name Application Type
TAB-623CL Bovine Anti-TNF Recombinant Antibody (TAB-623CL) Neut Bovine IgG

Humanized Antibody

CAT Product Name Application Type
TAB-124CQ Human Anti-TNF Recombinant Antibody (TAB-124CQ) FuncS, Neut Humanized antibody
TAB-125CQ Human Anti-TNF Recombinant Antibody (TAB-125CQ) ELISA, Neut Humanized antibody
TAB-126CQ Human Anti-TNF Recombinant Antibody (TAB-126CQ) ELISA, Neut Humanized antibody
TAB-127CQ Human Anti-TNF Recombinant Antibody (TAB-127CQ) ELISA, Neut Humanized antibody
TAB-128CQ Human Anti-TNF Recombinant Antibody (TAB-128CQ) ELISA, FuncS Humanized antibody

Non-hyper Galactosylated

CAT Product Name Application Type
Gly-083LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) ELISA, FC Human antibody

Sialylated IgG Glycan

CAT Product Name Application Type
Gly-085LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA, FC Human antibody
Gly-163LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA Chimeric antibody (mouse/human)

Recombinant Antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0609MZ Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY Indirect ELISA, WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-2057CQ Rat Anti-Tnf Recombinant Antibody (clone XT3) Block, ELISA, IHC, WB Rat IgG1
NEUT-2070CQ Mouse Anti-TNF Recombinant Antibody (clone 4F4) Block, ELISA, ICC, IF, IHC, WB Mouse IgG1
NEUT-2071CQ Rabbit Anti-TNF Recombinant Antibody (clone 6E10) Block, ELISA, IHC, WB Rabbit IgG1
NEUT-2082CQ Mouse Anti-TNF Recombinant Antibody (clone B-C7) Block Mouse IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-2080CQ Mouse Anti-TNF Recombinant Antibody (clone 4H31) WB, Neut, IHC-Fr, IP, FC Mouse IgG1
NEUT-2081CQ Mouse Anti-TNF Recombinant Antibody (clone 7J20) IHC, Neut, WB Mouse IgG1
NEUT-2083CQ Mouse Anti-TNF Recombinant Antibody (clone CBL209) WB, IHC, ICC, Neut Mouse IgG3
NEUT-2084CQ Mouse Anti-TNF Recombinant Antibody (clone CH8820) ELISA, IHC, Neut Mouse IgG1, κ
NEUT-2085CQ Mouse Anti-TNF Recombinant Antibody (clone mAb1) ELISA, FuncS, Neut Mouse IgG1, κ

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-768 Afuco™ Anti-TNF ADCC Recombinant Antibody (Nerelimomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-006 Afuco™ Anti-TNF ADCC Recombinant Antibody (Infliximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-010 Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced FC, IP, ELISA, Neut, FuncS ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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