Human Anti-TNF Recombinant Antibody (clone A2) (CAT#: PABL-349)
Recombinant Human Antibody (A2) is capable of binding to TNFA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-TNFA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-TNFA mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Figure 1 A graph showing neutralization of in vitro TNF cytotoxicity by murine A2. Control: murine IgG1 anti-lipid A mAb (8A1) with natural human TNF.
Figure 2 Graph showing that mAb A2 inhibits or neutralizes TNF produced by chimpanzee monocytes and rhTNFα.
Figure 3 Graph showing results of a cross-blocking epitope ELISA with murine A2 (mA2) antibody.
Specifications
- Immunogen
- Human tumor necrosis factor
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human TNF
- Species Reactivity
- Human
- Clone
- A2
- Applications
- WB, ELISA, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Neutralization and ELISA. For details, refer to Published Data.
Target
- Alternative Names
- TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF; monocyte-derived; TNF; macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2
- Gene ID
- 7124
- UniProt ID
- P01375
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-623CL | Bovine Anti-TNF Recombinant Antibody (TAB-623CL) | Neut | Bovine IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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