Recombinant Anti-human TNF VHH Single Domain Antibody

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Q&As

1. How does the binding specificity of Recombinant Anti-human TNF VHH Single Domain Antibodies compare to that of conventional monoclonal antibodies?

   A: The Recombinant Anti-human TNF VHH Single Domain Antibody exhibits exceptional specificity towards human TNF (Tumor Necrosis Factor). Compared to traditional monoclonal antibodies, this single domain antibody offers better tissue penetration due to its smaller size, higher stability, and ability to bind to unique epitopes that are less accessible to larger antibodies.

2. How does the single domain nature of this antibody impact its binding affinity and strength?

   A: The single domain nature of the antibody enhances its binding affinity and strength due to its streamlined structure which allows for closer contact with the antigen. This increased proximity helps in creating stronger intermolecular interactions, resulting in higher overall binding affinity.

3. What constraints or difficulties are associated with employing VHH single domain antibodies in clinical applications?

   A: While VHH single domain antibodies offer many advantages, they do have some limitations. One challenge is potential immunogenicity when used in humans, though engineering techniques such as humanization can mitigate this. Another challenge is ensuring consistent manufacturing standards to maintain quality and efficacy.

View the frequently asked questions answered by Creative Biolabs Support.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Protocol & Troubleshooting

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