Rituximab (CAT#: TP-082CL)

rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light- and heavy-chain variable region sequences and human constant region sequences. Rituximab is composed of two heavy chains of 451 amino acids and two light chains of 213 amino acids

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Normal Tissue
RNA Expression

Specifications

  • Type
  • Biotech
  • Trade name
  • rituximab
  • UNII
  • 4F4X42SYQ6

Target

  • Function
  • Chimeric (human/mouse) mAb that binds cD20, a transmembrane protein found on over 90% of B-cell non-Hodgkin's lymphomas (NHL); synergistic effect with some small-molecule chemotherapeutic agents has been demonstrated in lymphoma cell lines

Related Resources

  • Citations

Chen, Haizhang, et al. "Detection and functional resolution of soluble immune complexes by an FcγR reporter cell panel." EMBO Molecular Medicine 14.1 (2022): e14182.

This study focuses on developing a robust and scalable test system to detect and quantify the bioactivity of soluble IgG immune complexes (sICs). These complexes play a significant role in autoimmune diseases such as systemic lupus erythematosus (SLE). The researchers created a comprehensive panel of reporter cell lines that enable the quantification of sIC reactivity through ELISA or flow cytometry. This system identified FcγRIIA(H) and FcγRIIIA as the most sensitive receptors to sICs, allowing for the detailed analysis of sIC size and stoichiometry. The assay has shown predictive capabilities regarding the severity of SLE by analyzing sera from patients and mouse models, providing a sensitive tool to evaluate sICs in various settings.
Creative Biolabs contributed to this study by providing the pharmaceutical-grade humanized monoclonal IgG1 antibody rituximab (Cat# TP-082CL). Rituximab was crucial for generating soluble immune complexes (sICs) in the experiments. The study utilized recombinant CD20, obtained as a peptide containing the binding region of rituximab, to form these sICs. This setup allowed the researchers to create and analyze the immune complexes accurately. The high-quality rituximab provided by Creative Biolabs enabled the development of a sensitive and specific assay for detecting Fcγ receptor activation, which was essential for the study's success in evaluating the bioactivity and size of sICs.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Customer Reviews and Q&As

Customer Review Q&As

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  • Excellent for Rituximab Studies
    The Rituximab has been excellent for our CD20 studies. Its specificity and sensitivity are top-notch, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.
  • Reliable in Immunoassays
    We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for CD20 is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.
  • Consistent and High-Quality
    This antibody has proven to be consistent and high-quality in our assays. The reproducible results and strong affinity for CD20 have significantly improved our experiments, making it a crucial part of our research toolkit. The consistent performance has greatly enhanced our data quality.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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