A*02:01/Human Cyclin-dependent kinase inhibitor 1 (FAWERVRGL) MHC Pentamer (CAT#: MHC-YF387)
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed Cyclin-dependent kinase inhibitor 1-derived peptide of FAWERVRGL sequence covering 97-105 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RT4
(Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5946/1541_C12_6_selected.jpg
(Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5946/1541_C12_6_selected.jpg
Figure 2 IHC staining of human cervix, uterine
(Immunohistochemical staining of human cervix, uterine shows nuclear positivity in squamous cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/156817_B_8_3_selected.jpg
(Immunohistochemical staining of human cervix, uterine shows nuclear positivity in squamous cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/156817_B_8_3_selected.jpg
Figure 3 IHC staining of human urinary bladder
(Immunohistochemical staining of human urinary bladder shows strong nuclear positivity in urothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69401/155899_A_6_5_selected.jpg
(Immunohistochemical staining of human urinary bladder shows strong nuclear positivity in urothelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69401/155899_A_6_5_selected.jpg
Figure 4 Colon
(Glandular cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/159107_A_7_3.jpg
(Glandular cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/159107_A_7_3.jpg
Figure 5 Pancreas
(Pancreatic endocrine cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/159107_A_1_3.jpg
(Pancreatic endocrine cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/159107_A_1_3.jpg
Figure 6 Testis
(Leydig cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/159107_A_5_6.jpg
(Leydig cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/64/159107_A_5_6.jpg
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HSkMC, hTCEpi, LHCN-M2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000124762-CDKN1A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000124762-CDKN1A
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- Cyclin-dependent kinase inhibitor 1
- Antigen Species
- Human
- Peptide
- FAWERVRGL
- Range
- 97-105
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
- Alternative Names
- Cyclin Dependent Kinase Inhibitor 1A; Cyclin-Dependent Kinase Inhibitor 1A (P21, Cip1); CDK-Interacting Protein 1; CDKN1; CAP20; MDA-6; CIP1; SDI1; WAF1; P21;
- Gene ID
- 1026
- UniProt ID
- P38936
Downloads
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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