Anti-CDKN1A Recombinant Antibody Products

Loading...

Anti-CDKN1A Products

+ Filter

Loading...

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Creative Biolabs is here to help you with your oncology and cell cycle studies. Order top-tier anti-CDKN1A recombinant antibodies for research on this highly regulated protein p21, the major effector of the p53 tumor suppressor pathway. Check out our high-quality antibodies for use as an invaluable tool for measuring the DNA damage response, prognostication, and cell cycle arrest or senescence at a fundamental level.

CDKN1A: The Universal CDK Inhibitor

Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) is the gene that encodes p21 (also known as Waf1/Cip1), the archetypal inhibitor of the cell cycle. In the nucleus of the cell, p21 is induced mostly by the p53 tumor suppressor when DNA damage or oncogenic stress occurs. Once it is expressed, p21 directly binds and inhibits the main cell cycle kinases (CDK2, CDK4, and CDK6), resulting in a strong arrest of the cell in G1 or G2, to give time for repair of the damaged genome. P21 is crucial in preventing proliferation of damaged cells and in senescence. It is also one of the most studied biomarkers, as it is a direct readout of p53 activity.

Alternative Names

Cyclin Dependent Kinase Inhibitor 1A; Cyclin-Dependent Kinase Inhibitor 1A (P21, Cip1); CDK-Interacting Protein 1; CDKN1; CAP20; MDA-6; CIP1; SDI1; WAF1; P21

Background

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Anti-CDKN1A rAb Products

Creative Biolabs' anti-CDKN1A recombinant antibodies are designed for the highest specificity and optimal performance. Our antibodies are extensively validated for the specific detection of the p21 protein in nuclear extract or whole cell lysate (WCL). Optimized for use in Western Blot and IHC to confirm DNA damage signaling and cell cycle arrest, our rAbs are your go-to tool for cancer research.

Table 1. Featured anti-CDKN1A recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs does not compromise on scientific rigor. The development of our anti-CDKN1A recombinant antibodies is subject to a strict quality assurance system. Each lot is carefully tested for purity, specificity, and consistent performance in your validated applications (e.g., after irradiation or treatment of DNA damage).

Fig.1 WB analysis of anti-CDKN1A antibody (Cat# ZG-0913F, Creative Biolabs).

Customer Reviews

Excellent

Kat**n
Mouse Anti-CDKN1A Recombinant Antibody (clone WA-1)

We are working on a project related to senescence and this antibody has been a critical tool for us to confirm cell cycle arrest in our models by Western blot. A great and reliable product.

06/Dec/2024

rAb Production

Creative Biolabs supports cutting-edge oncology research with advanced production technologies. Our anti-CDKN1A recombinant antibodies are expressed in our optimized systems to ensure they faithfully recognize the native protein for a highly specific and active tool.

Featured Anti-CDKN1A Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-CDKN1A recombinant antibody production.

Fig.3 Gram-scale anti-CDKN1A recombinant antibody production.

rAb Modalities

Creative Biolabs is passionate about enabling scientific discovery through research antibody solutions. Our anti-CDKN1A recombinant antibodies are available in a variety of customizable modalities to meet your experimental needs.

Fig.4 Full-length anti-CDKN1A recombinant antibody production and modalities.

Don't let the details of the cell cycle checkpoint elude you! Order the rigorously validated and high-specificity anti-CDKN1A recombinant antibodies from Creative Biolabs for your work on this key tumor suppressor effector. Let our experienced team provide your research with the solid foundation it needs. Call or contact our specialists today!