A*02:01/Human ERBB-4 (VLVKSPNHV) MHC Pentamer (CAT#: MHC-YF427)

• Allele
• A*02:01

• Class
• Class I

• MHC Species
• Human

• Antigen
• ERBB-4

• Antigen Species
• Human

• Peptide
• VLVKSPNHV

• Range
• 890-898

• Conjugate
• Unlabeled, Biotin, R-PE, APC

• Application
• FCM

• Antigen Introduction
• This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

• Alternative Names
• Erb-B2 Receptor Tyrosine Kinase 4; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 4; Tyrosine Kinase-Type Cell Surface Receptor HER4; Human Epidermal Growth Factor Receptor 4; Proto-Oncogene-Like Protein C-ErbB-4; EC 2.7.10.1; P180erbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4;

• Gene ID
• 2066

• UniProt ID
• Q15303

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