A*02:01/HIV Nef (LTFGWCFKL) MHC Pentamer (CAT#: MHC-YF576)

• Allele
• A*02:01

• Class
• Class I

• MHC Species
• Human

• Antigen
• Nef

• Antigen Species
• HIV

• Peptide
• LTFGWCFKL

• Range
• 137-145

• Conjugate
• Unlabeled, Biotin, R-PE, APC

• Application
• FCM

• Antigen Introduction
• Extracellular Nef protein targets CD4+ T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors. Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike. Inhibits the Fas and TNFR-mediated death signals by blocking MAP3K5/ASK1. Decreases the half-life of TP53, protecting the infected cell against p53-mediated apoptosis. Inhibits the apoptotic signals regulated by the Bcl-2 family proteins through the formation of a Nef/PI3-kinase/PAK2 complex that leads to activation of PAK2 and induces phosphorylation of host BAD.

• Alternative Names
• Protein Nef; F-protein; nef

• Gene ID
• 156110

• UniProt ID
• A0EU06

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