A*11:01/HIV Nef (AVDLSHFLK) MHC Pentamer
CAT#: MHC-YF578
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed Nef-derived peptide of AVDLSHFLK sequence covering 84-92 and A*11:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
Specifications
- Allele
- A*11:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- Nef
- Antigen Species
- HIV
- Peptide
- AVDLSHFLK
- Range
- 84-92
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Extracellular Nef protein targets CD4+ T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors. Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike. Inhibits the Fas and TNFR-mediated death signals by blocking MAP3K5/ASK1. Decreases the half-life of TP53, protecting the infected cell against p53-mediated apoptosis. Inhibits the apoptotic signals regulated by the Bcl-2 family proteins through the formation of a Nef/PI3-kinase/PAK2 complex that leads to activation of PAK2 and induces phosphorylation of host BAD.
- Alternative Names
- Protein Nef; F-protein; nef
- Gene ID
- 156110
- UniProt ID
- A0EU06
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See other products for "HIV Nef"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-472 | Recombinant Anti-HIV Nef Antibody | ELISA, WB, FuncS | IgG |
| MHH-472 | Recombinant Human Anti-HIV Nef Antibody | FC, Neut, Biosensors, FuncS | IgG |
| MRO-754CQ | Mouse Anti-HIV Nef Recombinant Antibody (MRO-754CQ) | ELISA, IP, IF, WB | Mouse IgG1, κ |
| VS-0625-FY777 | Mouse Anti-nef Recombinant Antibody (clone 2506W0672) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-472-F(E) | Recombinant Anti-HIV Nef Antibody Fab Fragment | WB, FuncS | Fab |
| MHH-472-F(E) | Recombinant Human Anti-HIV Nef Antibody Fab Fragment | WB, Dot, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-472-S(P) | Recombinant Anti-HIV Nef Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-472-S(P) | Recombinant Human Anti-HIV Nef Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-022 | Recombinant Anti-HIV-1 nef VHH Single Domain Antibody (PNBL-022) | Inhib, WB, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF256 | Mafa-A1*063/SIV nef HW8 (HPAQTSQW) MHC Monomer | MHC Multimer | |
| MHC-YF257 | Mafa-A1*063/SIV nef RM9 (RPKVPLRTM) MHC Monomer | MHC Multimer | |
| MHC-YF259 | Mafa-B*104:01/SIV nef LT9 (LNMADKKET) MHC Monomer | MHC Multimer | |
| MHC-YC164 | A*11:01/Human Immunodeficiency virus 1 Nef protein (RYPLTFGW) MHC Pentamer | FCM | |
| MHC-YC168 | A*24:02/Human Immunodeficiency virus 1 Nef protein (RYPLTFGW) MHC Pentamer | FCM |
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