Anti-APOB (clone MabB23) Recombinant Antibody Coupled Liposome (VS-1024-FY12)
CAT#: VS-1024-FY12
Anti-ApoB conjugated liposomes involve the technique of binding anti-ApoB antibodies or related components to liposomes. This technology is used in the biomedical field for targeted delivery of drugs or genes. ApoB protein plays a crucial role in lipid metabolism and can reflect the risk of atherosclerosis. It has the potential to serve as a computed tomography imaging agent for the early detection of atherosclerotic plaques, which may assist in the diagnosis of early atherosclerosis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49793/762_C6_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows distinct positivity in plasma.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49793/ihc_selected.jpg
Normal Tissue
Figure 3 Duodenum
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16070/35958_A_8_2.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16070/35958_A_8_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000084674-APOB
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More Infomation
Specifications
- Potential Clinical Applications
- Early detection of atherosclerotic plaques
Product Composition
- Clone
- MabB23
- Antibody Type
- IgG2b
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant mouse antibody that specifically binds to apolipoprotein B (APOB), with the immunogen being human apolipoprotein B-100 and demonstrating specificity for human plasma apolipoprotein B-100.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- APOB
- Introduction
- This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
- Alternative Names
- Apolipoprotein B; Apolipoprotein B (Including Ag(X) Antigen); Apolipoprotein B-100; Apolipoprotein B48; Apo B-100; ApoB-100; ApoB-48; LDLCQ4; FLDB
- Full Name
- Apolipoprotein B
- Gene ID
- 338
- UniProt ID
- P04114
- Cellular Localization
- Cytoplasm, Lipid droplet
- Post Translation Modifications
- Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.
- Protein Refseq
- NP_000375.3
- Function
- Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone MabB23"
- CAT
- Product Name
See other products for "APOB"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1364z | Mouse Anti-APOB Recombinant Antibody (clone 21F3) | ELISA, FC, ICC, IF, WB | Mouse IgG1 |
| MOB-0666MZ | Mouse Anti-APOB Recombinant Antibody (clone 23H20) | FC | Mouse IgG1 |
| FAMAB-0013CQ | Mouse Anti-APOB Recombinant Antibody (clone MabB23) | ELISA | Mouse IgG2b, λ |
| FAMAB-0014CQ | Mouse Anti-APOB Recombinant Antibody (clone MabB9) | ELISA | Mouse IgG2b, κ |
| VS3-XY3262 | Rabbit Anti-APOB Recombinant Antibody (clone R02-6G3) | WB, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-015 | Recombinant Anti-Human Apob VHH Single Domain Antibody | CA, IP, IF, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0207 | Hi-Affi™ Rabbit Anti-APOB Recombinant Antibody (clone DS207AB) | WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0013CQ-F(E) | Mouse Anti-APOB Recombinant Antibody (clone MabB23); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0014CQ-F(E) | Mouse Anti-APOB Recombinant Antibody (clone MabB9); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0013CQ-S(P) | Mouse Anti-APOB Recombinant Antibody (clone MabB23); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0014CQ-S(P) | Mouse Anti-APOB Recombinant Antibody (clone MabB9); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY454 | Anti-APOB Immunohistochemistry Kit | IHC | |
| VS-0525-XY455 | Anti-Human APOB Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC22 | Recombinant Anti-APOB Eliminating Antibody, pH-Sensitive (MabB23 var.) | Antigen-Sweeping In Vivo. | Mouse IgG2b lambda |
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