Anti-APOB (clone MabB23) Recombinant Antibody Coupled Liposome (VS-1024-FY12) (CAT#: VS-1024-FY12)

• Potential Clinical Applications
• Early detection of atherosclerotic plaques

• Clone
• MabB23

• Antibody Type
• IgG2b

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant mouse antibody that specifically binds to apolipoprotein B (APOB), with the immunogen being human apolipoprotein B-100 and demonstrating specificity for human plasma apolipoprotein B-100.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• APOB

• Introduction
• This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.

• Alternative Names
• Apolipoprotein B; Apolipoprotein B (Including Ag(X) Antigen); Apolipoprotein B-100; Apolipoprotein B48; Apo B-100; ApoB-100; ApoB-48; LDLCQ4; FLDB

• Full Name
• Apolipoprotein B

• Gene ID
• 338

• UniProt ID
• P04114

• Cellular Localization
• Cytoplasm, Lipid droplet

• Post Translation Modifications
• Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.

• Protein Refseq
• NP_000375.3

• Function
• Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

• FAMAB-0013CQ
• Mouse Anti-APOB Recombinant Antibody (clone MabB23)

• FAMAB-0013CQ-F(E)
• Mouse Anti-APOB Recombinant Antibody (clone MabB23); Fab Fragment

• FAMAB-0013CQ-S(P)
• Mouse Anti-APOB Recombinant Antibody (clone MabB23); scFv Fragment

• FAMAB-0013CQ-mRNA
• Mouse Anti-APOB Antibody (clone MabB23), mRNA

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