Mouse Anti-ASRGL1 Recombinant Antibody (clone CRASH/1290) (CAT#: VS-0625-FY16)

• Host Species
• Mouse

• Type
• Mouse IgG1

• Species Reactivity
• Human

• Clone
• CRASH/1290

• Applications
• ELISA

• Related Disease
• Aniridia 1 and Retinal Disease

• Purification
• Purified with Protein A or G affinity chromatography

• Purity
• >90% as determined by SDS-PAGE

• Molecular Weight
• The predicted antigen size is approximately 17-25 kDa.

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Optimal dilutions for assays should be determined by the user.

• Alternative Names
• Asparaginase Like 1; Asparaginase-Like 1 Protein; Asparaginase-Like Protein 1; L-Asparagine Amidohydrolase; Isoaspartyl Dipeptidase; Beta-Aspartyl-Peptidase; EC 3.5.1.1; CRASH

• Gene ID
• 80150

• UniProt ID
• Q7L266

• Long Name
• Asparaginase Like 1

• Sequence Similarities
• Belongs to the Ntn-hydrolase family.

• Cellular Localization
• Cytoplasm

• Post Translation Modifications
• Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme.
  The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.

• Protein Refseq
• XP_011543567.1; XP_011543568.1; XP_047283587.1; XP_047283588.1; XP_054226000.1

• Function
• Has both L-asparaginase and beta-aspartyl peptidase activity.
  May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions.
  Is highly active with L-Asp beta-methyl ester.
  Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys.
  Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn.
  Likewise, has no activity toward glutamine.

Secondary Antibody

• 2ND-047CQ
• Goat Anti-Mouse IgG1 Antibody, R-PE

• 2RD-A1460-YJ
• Goat Anti-Mouse IgG1 Secondary antibody

Isotype Control

• MOB-065CQ
• Mouse IgG1 Isotype Control Antibody

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