AbPlus™ Anti-CCND2 Magnetic Beads (DCS-3.1)
CAT#: VS-0424-XY45
The AbPlus Anti-CCND2 Magnetic Beads (DCS-3.1) is an innovative affinity resin which is bound with anti-CCND2 specific antibody (DCS-3.1). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of CCND2 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49138/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54196/if_selected.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49138/110519_A_9_5.jpg
Normal Tissue
Figure 4 Epididymis
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49138/110519_A_3_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, HBEC3-KT, HDLM-2, Karpas-707, RH-30, RPMI-8226)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118971-CCND2
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-CCND2 specific antibody (DCS-3.1)
- Target
- CCND2
- Immunogen
- Purified human recombinant full length cyclin D2 protein with histidine-tag.
- Target Species
- Human, Mouse, Rat
- Antibody Clone
- DCS-3.1
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).
- Alternative Names
- CCND2; cyclin D2; MPPH3; KIAK0002
- Gene ID
- 894
- UniProt ID
- P30279
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Related Signaling Pathways
Hedgehog Signaling Pathway
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Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
| MOB-2080z | Mouse Anti-CCND2 Recombinant Antibody (clone 33G12) | WB, ICC, IF | Mouse IgG2a |
| MOB-2383CT | Mouse Anti-CCND2 Recombinant Antibody (clone L7) | IF, FC, WB | Mouse IgG |
| ZG-0447F | Mouse Anti-CCND2 Recombinant Antibody (ZG-0447F) | WB | Mouse IgG |
| VS3-QX175 | Mouse Anti-CCND2 Recombinant Antibody (clone 6E11-G6-F5) | WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
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| NEUT-263CQ | Mouse Anti-CCND2 Recombinant Antibody (clone CBL925) | FC, IF, IP, ICC, WB, Neut | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-264CQ | Mouse Anti-CCND2 Recombinant Antibody (clone DCS-3.1) | FC, Inhib, IF, IHC, IP, WB | Mouse IgG2a |
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