Anti-CD3E Antibody Prodrug, Protease Activated (VS-1025-YC3)
CAT#: VS-1025-YC3
The Anti-CD3E Antibody Prodrug, Protease Activated (VS-1025-YC3) is an antibody prodrug comprised of a recombinant hamster antibody targeting mouse CD3E, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CD3E protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CD3E effectively. CD3 epsilon is a necessary component of the T-cell Receptor (TCR) complex, which is essential for the T-cell to recognize and eliminate tumor cells; therefore, its relevance is purely immunotherapeutic. In cancer therapy, the murine CD3 complex is strategically engaged by bispecific antibodies that simultaneously bind both a tumor antigen and CD3, forcibly activating the T-cell to execute a precise, targeted attack on the tumor.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line JURKAT
Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane & endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40957/1970_E5_1_selected.jpg
Normal Tissue
Figure 2 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72864/157655_A_9_8.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198851-CD3E
❮
❯
Specifications
- Host Animal
- Hamster
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Mouse CD3E
- Target
- CD3E
- Species Reactivity
- Mouse
- Isotype
- IgG
- Masking Approach
- Steric mask
- Mask
- Coiled-coiled domains
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
- Alternative Names
- CD3; T3e; AI504783; CD3epsilon
- Gene ID
- 12501
- UniProt ID
- P22646
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1025-YC3. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CD3E"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H28 | Anti-Human CD3E Recombinant Antibody (Ertumaxomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-988 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1) | FC, IHC, WB, FuncS, IF | Mouse IgG1 F(ab')2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-989 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1); Fab Fragment | FC, Cyt, Stim, PP, Agonist | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-714 | Anti-CD3E Recombinant Antibody (Visilizumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-159 | Anti-Human CD3E Recombinant Antibody (TAB-159) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H52 | Anti-Human CD3E Recombinant Antibody (TAB-H52) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-245 | Anti-Human CD3 epsilon Recombinant Antibody (TAB-245) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-019 | Anti-Human CD3 Recombinant Antibody (TAB-019) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG2a - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G010E | Anti-CD3E immunotoxin UCHT1 (scFv)-PE | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G010D | Anti-CD3E immunotoxin UCHT1 (scFv)-DT | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G010R | Anti-CD3E immunotoxin UCHT1 (scFv)-RTA | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L049E | Anti-CD3E immunotoxin (IgG)-PE | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L049D | Anti-CD3E immunotoxin (IgG)-DT | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-124CL | Human Anti-CD3E Recombinant Antibody (TAB-124CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0203MC | Hamster Anti-CD3E Recombinant Antibody (MOB-0203MC) | FC, IHC, IF, IP, WB | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-600NL | Recombinant Anti-mouse CD3e Antibody. | IP, IHC-Fr, FuncS, ICC, FACS |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-648 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11) | WB, IHC, IF, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-643 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11); Fab Fragment | WB, IHC, IF, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-643 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2278MZ | Mouse Anti-CD3E Recombinant Antibody (clone QT2) | IHC-P | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-032 | Recombinant Grey hamster Anti-CD3E Antibody (2C11) | WB, ELISA, FuncS, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-033 | Recombinant Grey hamster Anti-CD3E Antibody (17A2) | WB, ELISA, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-032-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (2C11) | WB, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-033-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (17A2) | WB, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-032-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (2C11) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-033-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (17A2) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0558 | Hi-Affi™ Rabbit Anti-CD3E Recombinant Antibody (clone DS558AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-420CQ | Anti-Human CD3E Recombinant Antibody (Visilizumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0049-YC-S(P) | Hamster Anti-CD3E Recombinant Antibody scFv Fragment (FAMAB-0049-YC-S(P)) | FC, FuncS | Hamster scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0052-YC-S(P) | Hamster Anti-CD3E Recombinant Antibody (clone 500A2); scFv Fragment | ELISA | Hamster scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0049-YC-F(E) | Hamster Anti-CD3E Recombinant Antibody Fab Fragment (FAMAB-0049-YC-F(E)) | FC, FuncS | Hamster Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0052-YC-F(E) | Hamster Anti-CD3E Recombinant Antibody (clone 500A2); Fab Fragment | ELISA | Hamster Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0047CQ | Mouse Anti-CD3E Recombinant Antibody (clone CLB-T3/4.1) | ELISA, IF, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0047CQ-S(P) | Mouse Anti-CD3E Recombinant Antibody (clone CLB-T3/4.1); scFv Fragment | ELISA, IF, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-159 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-159) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-245 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-245) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H52 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H52) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-714 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-714) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-019 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-019) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0263-YJ-S(P) | Rabbit Anti-CD3E Recombinant Antibody (clone 645); scFv Fragment | ELISA, FC, FuncS | Rabbit scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0058-FY | Rabbit Anti-CD3E Recombinant Antibody (clone AFY0029) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY17 | Mouse Anti-CD3E Agonistic Antibody (VS-0724-XY17) | FC, IP, ICC, Agonistic assays | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1433 | AbPlus™ Anti-CD3E Magnetic Beads (VS-0724-YC1433) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY94 | Mouse Anti-NHP CD3E Recombinant Antibody (clone FN-18) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY46 | CytoStream™ Mouse Anti-CD3E Recombinant Antibody (clone 1F4) | FC | Mouse IgM, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY47 | CytoStream™ Mouse Anti-CD3E Recombinant Antibody (clone SK7) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY110 | Human Anti-CD3E (clone NI-0401) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC355 | Recombinant Anti-CD3E Vesicular Antibody, EV Displayed (VS-0425-YC355) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1171 | Anti-CD3E Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1172 | Anti-Mouse CD3E Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: WB, IP, IF, FuncS, FC, Neut, ELISA
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: ELISA, WB, BLI, SPR
Application: Block, Cyt, FuncS, Inhib
Application: ELISA, Neut, FuncS
Application: Neut, ELISA, FuncS
Application: WB, ELISA, FuncS
Application: ELISA, IP, WB, IHC, IF, FuncS
Application: Neut, ELISA, Inhib, ICC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
