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CD3E

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The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.

Derivation:
Rat
Species Reactivity:
Human
Type:
IgG2a - kappa / G2b - lambda
Application:
IF, IP, Neut, FuncS, ELISA, FC, WB
Derivation:
Rat
Species Reactivity:
Human
Type:
IgG2a / G2b
Application:
ELISA, FC, IP, FuncS, IF, Neut, ICC
Species Reactivity:
Human
Type:
F(ab')2
Application:
FC, PS, WB
Species Reactivity:
Human
Type:
Fab
Application:
FC, PS, WB
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2
Application:
FuncS, IF, Neut, ELISA, FC, IP, ICC
Derivation:
Humanized
Species Reactivity:
Human
Type:
(scFv - heavy - kappa) - (scFv - heavy - lambda)
Application:
FC, IP, ELISA, Neut, FuncS, IF, ICC
Derivation:
Human
Species Reactivity:
Human
Type:
Antibody
Target:
CD3
Species Reactivity:
Human
Cytokine 1:
IL2
Host:
Mouse
Cytokine 1 Species:
Human
Molecule Class:
IL2-IgGa
Target:
CD3
Species Reactivity:
Human
Cytokine 1:
TNF
Host:
Mouse
Cytokine 1 Species:
Human
Molecule Class:
TNF-IgGa
Species Reactivity:
Mouse
Application:
FC, IHC, IF, IP, WB
Species Reactivity:
Mouse
Application:
IP, IHC-Fr, FuncS, ICC, FACS
Derivation:
Humanized (from rat)
Species Reactivity:
Human
Type:
IgG1 - lambda
Application:
FC, IP, ELISA, Neut, FuncS, IF, WB
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, ELISA, FC, IP, FuncS, IF, Neut
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG2a - kappa
Application:
FC, IP, ELISA, Neut, FuncS, IF, WB
Derivation:
Mouse
Species Reactivity:
Mouse
Type:
IgG
Application:
WB, IHC, IF, FuncS
Targets:
FAP & CD3e
Type:
BiTE
Application:
FC, ELISA
Targets:
FAP & CD3e
Type:
BiTE
Application:
FC, ELISA
Targets:
FAP & CD3e
Type:
BiTE
Application:
FC, ELISA
Targets:
FAP & CD3e
Type:
BiTE
Application:
FC, ELISA
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