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CD3E

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The CD3E molecule (epsilon) is a polypeptide that is encoded in humans by the CD3E gene located on chromosome 11. The protein encoded by this gene is a CD3-epsilon polypeptide that forms a T cell receptor-CD3 complex with CD3-gamma, -delta and -indole, and T cell receptor alpha/beta and gamma/delta heterodimers. This complex plays an important role in coupling antigen recognition to several intracellular signal transduction pathways. The genes encoding epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an important role in the development of T cells. Defects in this gene result in severe immune deficiency. This gene is also associated with women predisposed to Type I diabetes. The T cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B, CD3 EAP and NCK2. Muromonab-CD3 (trade name Orthoclone OKT3) is an immunosuppressive drug used to reduce acute rejection in organ transplant patients. It is a monoclonal antibody against the CD3 receptor, a membrane protein on the surface of T cells. Muromonab-CD3 is approved for the treatment of acute glucocorticoid-resistant rejection of allograft kidney, heart and liver transplants. It is also used to treat T-cell acute lymphoblastic leukemia.

Derivation:
Humanized (from rat)
Species Reactivity:
Human
Type:
IgG1 - lambda
Application:
FC, IP, ELISA, Neut, FuncS, IF, WB
Derivation:
Human
Species Reactivity:
Human
Type:
IgG1 - kappa
Application:
WB, ELISA, FC, IP, FuncS, IF, Neut
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG2a - kappa
Application:
FC, IP, ELISA, Neut, FuncS, IF, WB
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Application:
Cytotoxicity assay, Functional assay
Derivation:
Human
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Derivation:
Mouse
Species Reactivity:
Mouse
Type:
Fab
Application:
WB, IHC, IF, FuncS
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Derivation:
Human
Species Reactivity:
Human
Type:
Antibody
Target:
CD3
Species Reactivity:
Human
Cytokine 1:
IL2
Host:
Mouse
Cytokine 1 Species:
Human
Molecule Class:
IL2-IgGa
Target:
CD3
Species Reactivity:
Human
Cytokine 1:
TNF
Host:
Mouse
Cytokine 1 Species:
Human
Molecule Class:
TNF-IgGa
Species Reactivity:
Mouse
Application:
FC, IHC, IF, IP, WB
Species Reactivity:
Mouse
Application:
IP, IHC-Fr, FuncS, ICC, FACS
Derivation:
Mouse
Species Reactivity:
Mouse
Type:
IgG
Application:
WB, IHC, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Mouse
Type:
scFv
Application:
WB, IHC, IF, FuncS
Derivation:
Grey hamster
Species Reactivity:
Mouse
Type:
Fab
Application:
WB, ELISA, FuncS
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