CD3E

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Anti-CD3E Products

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    • Species Reactivity: Bovine, Cat, Chicken, Dog, Duck, Horse, Human, Mouse, Pig, Rabbit, Xenopus
    • Type: Rat mAb
    • Application: FC, ICC, IF, IHC, WB
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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
CD3E
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