Anti-CD3E immunotoxin UCHT1 (scFv)-RTA (CAT#: AGTO-G010R)

This immunotoxin was achieved by conjugating/fusing the Anti-CD3E scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD3ε positive T cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell malignancies.


Specific Inquiry
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  • Datasheet
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  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Clone
  • UCHT1
  • Molecule Class
  • scFv-RTA
  • Toxin Description
  • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • T cell malignancies

Target

  • Alternative Names
  • CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone UCHT1"

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Rat Antibody

CAT Product Name Application Type
TAB-H28 Anti-Human CD3E Recombinant Antibody (Ertumaxomab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG2a / G2b

Humanized Antibody

CAT Product Name Application Type
TAB-714 Anti-CD3E Recombinant Antibody (Visilizumab) FuncS, IF, Neut, ELISA, FC, IP, ICC IgG2
TAB-H52 Anti-Human CD3E Recombinant Antibody (Otelixizumab) FC, IP, ELISA, Neut, FuncS, IF, WB IgG1 - lambda
TAB-420CQ Anti-Human CD3E Recombinant Antibody (Visilizumab) ELISA, IHC, FC, IP, IF, FuncS IgG2, κ

Human Antibody

CAT Product Name Application Type
TAB-245 Anti-Human CD3 epsilon Recombinant Antibody (Foralumab) WB, ELISA, FC, IP, FuncS, IF, Neut IgG1 - kappa
TAB-124CL Human Anti-CD3E Recombinant Antibody (TAB-124CL) ELISA Human IgG

Mouse Antibody

Immunotoxin

CAT Product Name Application Type
AGTO-G010E Anti-CD3E immunotoxin UCHT1 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G010D Anti-CD3E immunotoxin UCHT1 (scFv)-DT Cytotoxicity assay, Function study
AGTO-L049E anti-CD3E immunotoxin UCHT1 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L049D anti-CD3E immunotoxin UCHT1 (IgG)-DT Cytotoxicity assay, Functional assay
AGTO-L049R anti-CD3E immunotoxin UCHT1 (IgG)-RTA Cytotoxicity assay, Functional assay

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-245 Afuco™ Anti-CD3E ADCC Recombinant Antibody (Foralumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody
AFC-TAB-H52 Afuco™ Anti-CD3E ADCC Recombinant Antibody (Otelixizumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-714 Afuco™ Anti-CD3E ADCC Recombinant Antibody (Visilizumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-019 Afuco™ Anti-CD3E ADCC Recombinant Antibody (Muromonab-Cd3), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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