Anti-Human CD3E Recombinant Antibody (Ertumaxomab)

Name: Anti-Human CD3E Recombinant Antibody (Ertumaxomab)
SKU: TAB-H28
Rating: 5 (1 reviews)

CAT#: TAB-H28

This product is a recombinant antibody that targets human CD3E and ERBB2. Ertumaxomab is a so-called trifunctional antibody which works by linking T-lymphocytes and macrophages to the cancer cells.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line JURKAT

Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane & endoplasmic reticulum.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40957/1970_E5_1_selected.jpg

Normal Tissue Figure 2 Lymph node

Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72864/157655_A_9_8.jpg

RNA Expression Figure 3 RNA cell line category: Group enriched (JURKAT, MOLT-4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198851-CD3E

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Specifications

Host Species
Human

Derivation
Rat

Type
IgG1

Specificity
CD3E (CD3 epsilon) [Homo sapiens] ;

Species Reactivity
Human

Applications
ELISA, FC, IP, FuncS, IF, Neut, ICC, Cyt, Stim

Generic Name
ertumaxomab

Related Disease
Breast cancers

Product Property

Purity
>95.0% as determined by analysis by SDS-PAGE.

Applications

Application Notes
The CD3E antibody has been reported in applications of ELISA, FC, IP, FuncS, IF, Neut, ICC, Cyt, Stim.

Target

Alternative Names
ertumaxomab;rexomun;509077-99-0;2502A/TP- A-02/TPBs03;CD3E;CD3e molecule, epsilon (CD3-TCR complex);CD3e antigen, epsilon polypeptide (TiT3 complex);T-cell surface glycoprotein CD3 epsilon chain;CD3-epsilon;T-cell surface antigen T3/Leu-4 epsilon chain;T-

Gene ID
916

UniProt ID
P07766

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Biosimilar Overview

Please refer to Ertumaxomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ertumaxomab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-H28.pdf

MSDS

MSDS - TAB-H28.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "ertumaxomab"

DrugMonitor™ Anti-Ertumaxomab Antibody (VS-1224-YC447)
Ertumaxomab is an intact bispecific antibody targeting HER2/neu and CD3, with preferential binding to activating Fc gamma type I/III-receptors, under investigation for metastatic breast cancer treatment after trastuzumab progression. The DrugMonitor™ Anti-Ertumaxomab Antibody (VS-1224-YC447) is an anti-drug antibody (ADA) against Ertumaxomab. This drug-based antibody is raised in mice immunized with the Ertumaxomab. The anti-Ertumaxomab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Ertumaxomab in samples.

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