Anti-Human CD3E Recombinant Antibody (Ertumaxomab) (CAT#: TAB-H28)
Recombinant Rat antibody to Human CD3E. Ertumaxomab (trade name Rexomun) is a rat-murine hybrid monoclonal antibody designed to treat some types of cancer. It is a so-called trifunctional antibody which works by linking T-lymphocytes and macrophages to the cancer cells.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line JURKAT
(Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane & endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40957/1970_E5_1_selected.jpg
(Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane & endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40957/1970_E5_1_selected.jpg
Figure 2 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72864/157655_A_9_8.jpg
(Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72864/157655_A_9_8.jpg
Figure 3 RNA cell line category: Group enriched (JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198851-CD3E
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198851-CD3E
Specifications
- Host Species
- Rat
- Derivation
- Rat
- Type
- IgG2a / G2b
- Specificity
- CD3E (CD3 epsilon) [Homo sapiens] ;
- Species Reactivity
- Human
- Applications
- ELISA, FC, IP, FuncS, IF, Neut, ICC, Cyt, Stim
- Trade name
- rexomun
- CAS
- 509077-99-0
- Generic Name
- ertumaxomab
- Related Disease
- Breast cancers
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
Applications
- Application Notes
- The CD3E antibody has been reported in applications of ELISA, FC, IP, FuncS, IF, Neut, ICC, Cyt, Stim.
Target
- Alternative Names
- ertumaxomab;rexomun;509077-99-0;2502A/TP- A-02/TPBs03;CD3E;CD3e molecule, epsilon (CD3-TCR complex);CD3e antigen, epsilon polypeptide (TiT3 complex);T-cell surface glycoprotein CD3 epsilon chain;CD3-epsilon;T-cell surface antigen T3/Leu-4 epsilon chain;T-
- Gene ID
- 916
- UniProt ID
- P07766
Related Resources
Please refer to Ertumaxomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ertumaxomab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Ertumaxomab"
DrugMonitor™ Anti-Ertumaxomab Antibody (VS-1224-YC447)Ertumaxomab is an intact bispecific antibody targeting HER2/neu and CD3, with preferential binding to activating Fc gamma type I/III-receptors, under investigation for metastatic breast cancer treatment after trastuzumab progression. The DrugMonitor™ Anti-Ertumaxomab Antibody (VS-1224-YC447) is an anti-drug antibody (ADA) against Ertumaxomab. This drug-based antibody is raised in mice immunized with the Ertumaxomab. The anti-Ertumaxomab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Ertumaxomab in samples.
See other products for "CD3E"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-988 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1) | FC, IHC, WB, FuncS, IF | Mouse IgG1 F(ab')2 |
| DrMAB-989 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1); Fab Fragment | FC, Cyt, Stim, PP, Agonist | Mouse Fab |
| PFBL-643 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11); Fab Fragment | WB, IHC, IF, FuncS | Mouse Fab |
| HPAB-0347-YJ-F(E) | Rat Anti-CD3E Recombinant Antibody (clone 1Ab); Fab Fragment | FC, WB, Inhib | Rat Fab |
| HPAB-0385-FY-F(E) | Human Anti-CD3E Recombinant Antibody; Fab Fragment (HPAB-0385-FY-F(E)) | Activ | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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