Anti-Human CD3E Recombinant Antibody (Ertumaxomab)
CAT#: TAB-H28
Recombinant Rat antibody to Human CD3E. Ertumaxomab (trade name Rexomun) is a rat-murine hybrid monoclonal antibody designed to treat some types of cancer. It is a so-called trifunctional antibody which works by linking T-lymphocytes and macrophages to the cancer cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line JURKAT
Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane & endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40957/1970_E5_1_selected.jpg
Normal Tissue
Figure 2 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72864/157655_A_9_8.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198851-CD3E
❮
❯
Specifications
- Host Species
- Rat
- Derivation
- Rat
- Type
- IgG2a / G2b
- Specificity
- CD3E (CD3 epsilon) [Homo sapiens] ;
- Species Reactivity
- Human
- Applications
- ELISA, FC, IP, FuncS, IF, Neut, ICC, Cyt, Stim
- Trade name
- rexomun
- CAS
- 509077-99-0
- Generic Name
- ertumaxomab
- Related Disease
- Breast cancers
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
Applications
- Application Notes
- The CD3E antibody has been reported in applications of ELISA, FC, IP, FuncS, IF, Neut, ICC, Cyt, Stim.
Target
- Alternative Names
- ertumaxomab;rexomun;509077-99-0;2502A/TP- A-02/TPBs03;CD3E;CD3e molecule, epsilon (CD3-TCR complex);CD3e antigen, epsilon polypeptide (TiT3 complex);T-cell surface glycoprotein CD3 epsilon chain;CD3-epsilon;T-cell surface antigen T3/Leu-4 epsilon chain;T-
- Gene ID
- 916
- UniProt ID
- P07766
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Biosimilar Overview
Please refer to Ertumaxomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ertumaxomab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Ertumaxomab"
DrugMonitor™ Anti-Ertumaxomab Antibody (VS-1224-YC447)Ertumaxomab is an intact bispecific antibody targeting HER2/neu and CD3, with preferential binding to activating Fc gamma type I/III-receptors, under investigation for metastatic breast cancer treatment after trastuzumab progression. The DrugMonitor™ Anti-Ertumaxomab Antibody (VS-1224-YC447) is an anti-drug antibody (ADA) against Ertumaxomab. This drug-based antibody is raised in mice immunized with the Ertumaxomab. The anti-Ertumaxomab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Ertumaxomab in samples.
See other products for "CD3E"
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-245 | Anti-Human CD3 epsilon Recombinant Antibody (TAB-245) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG1 - kappa |
| TAB-124CL | Human Anti-CD3E Recombinant Antibody (TAB-124CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
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| TAB-019 | Anti-Human CD3 Recombinant Antibody (TAB-019) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG2a - kappa |
| PABX-032-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (2C11) | WB, ELISA, FuncS | scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G010E | Anti-CD3E immunotoxin UCHT1 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G010D | Anti-CD3E immunotoxin UCHT1 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-G010R | Anti-CD3E immunotoxin UCHT1 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-L049E | Anti-CD3E immunotoxin (IgG)-PE | Cytotoxicity assay, Functional assay | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-648 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11) | WB, IHC, IF, FuncS | Mouse IgG |
| FAMAB-0047CQ | Mouse Anti-CD3E Recombinant Antibody (clone CLB-T3/4.1) | ELISA, IF, IP | Mouse IgG1 |
| HPAB-0263-YJ | Rabbit Anti-CD3E Recombinant Antibody (clone 645) | ELISA, FC, FuncS | Rabbit IgG1 |
| HPAB-0385-FY | Human Anti-CD3E Recombinant Antibody (HPAB-0385-FY) | Activ | Human IgG1 |
| HPAB-A1283-YJ | Hamster Anti-CD3E Recombinant Antibody (clone 145.2c11) | ELISA, WB, IP, FC, FuncS, Inhib | Hamster IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-643 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11); Fab Fragment | WB, IHC, IF, FuncS | Mouse Fab |
| FAMAB-0049-YC-F(E) | Hamster Anti-CD3E Recombinant Antibody Fab Fragment (FAMAB-0049-YC-F(E)) | FC, FuncS | Hamster Fab |
| FAMAB-0052-YC-F(E) | Hamster Anti-CD3E Recombinant Antibody (clone 500A2); Fab Fragment | ELISA | Hamster Fab |
| FAMAB-0047CQ-F(E) | Mouse Anti-CD3E Recombinant Antibody (clone CLB-T3/4.1); Fab Fragment | ELISA, IF, IP | Mouse Fab |
| HPAB-0385-FY-F(E) | Human Anti-CD3E Recombinant Antibody; Fab Fragment (HPAB-0385-FY-F(E)) | Activ | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-643 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
| FAMAB-0049-YC-S(P) | Hamster Anti-CD3E Recombinant Antibody scFv Fragment (FAMAB-0049-YC-S(P)) | FC, FuncS | Hamster scFv |
| HPAB-0263-YJ-S(P) | Rabbit Anti-CD3E Recombinant Antibody (clone 645); scFv Fragment | ELISA, FC, FuncS | Rabbit scFv |
| HPAB-0347-YJ-S(P) | Rat Anti-CD3E Recombinant Antibody (clone 1Ab); scFv Fragment | FC, WB, Inhib | Rat scFv |
| HPAB-0385-FY-S(P) | Human Anti-CD3E Recombinant Antibody; scFv Fragment (HPAB-0385-FY-S(P)) | Activ | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-032 | Recombinant Grey hamster Anti-CD3E Antibody (2C11) | WB, ELISA, FuncS, IP | IgG |
| PABX-033 | Recombinant Grey hamster Anti-CD3E Antibody (17A2) | WB, ELISA, FuncS | IgG |
| PABX-032-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (2C11) | WB, ELISA, FuncS | Fab |
| PABX-033-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (17A2) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0558 | Hi-Affi™ Rabbit Anti-CD3E Recombinant Antibody (clone DS558AB) | IHC-P | Rabbit IgG |
| MOR-0058-FY | Rabbit Anti-CD3E Recombinant Antibody (clone AFY0029) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-159 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-159) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-245 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-245) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H52 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H52) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-714 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-714) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-019 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-019) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY17 | Mouse Anti-CD3E Agonistic Antibody (VS-0724-XY17) | FC, IP, ICC, Agonistic assays | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1433 | AbPlus™ Anti-CD3E Magnetic Beads (VS-0724-YC1433) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY94 | Mouse Anti-NHP CD3E Recombinant Antibody (clone FN-18) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| VS-0225-XY47 | CytoStream™ Mouse Anti-CD3E Recombinant Antibody (clone SK7) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY110 | Human Anti-CD3E (clone NI-0401) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC355 | Recombinant Anti-CD3E Vesicular Antibody, EV Displayed (VS-0425-YC355) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1171 | Anti-CD3E Immunohistochemistry Kit | IHC | |
| VS-0525-XY1172 | Anti-Mouse CD3E Immunohistochemistry Kit | IHC |
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