1 0
Cart
    Inquiry
    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

    Human Anti-CD3E (clone NI-0401) scFv-Fc Chimera

    CAT#: VS-0325-FY110

    The anti-CD3E scFv-Fc antibody specifically binds to CD3ε, a subunit of the T cell receptor (TCR)complex. Its scFv-Fc format enhances its ability to modulate T cell activation and immune responses. This antibody is valuable for research on T cell signaling pathways and immune checkpoint mechanisms.

    Gene Expression
    ❮
    Figure 1 IF staining of human cell line JURKAT Figure 2 Lymph node Figure 3 RNA cell line category: Group enriched (JURKAT, MOLT-4)
    ❯

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • Human CD3E
    • Species Reactivity
    • Human
    • Clone
    • NI-0401
    • Applications
    • ELISA

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • Assay-dependent

    Target

    • Alternative Names
    • CD3e Molecule; CD3e Antigen, Epsilon Polypeptide (TiT3 Complex); T-Cell Surface Antigen T3/Leu-4 Epsilon Chain; CD3e Molecule, Epsilon (CD3-TCR Complex); T3E; T-Cell Antigen Receptor Complex, Epsilon Subunit Of T3
    • Long Name
    • CD3e Molecule
    • Cellular Localization
    • Cell membrane; Membrane
    • Post Translation Modifications
    • Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
    • Function
    • Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098).
      In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).
    REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
    Inquiry
    Navs

    Customer Review

    Submit a review or a question

    There are currently no Customer reviews or questions for VS-0325-FY110. Click the button above to contact us or submit your feedback about this product.

    Submit Your Publication

    Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

    Article title:
    DOI/PubMed URL:
    Email:
    Name:

    This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

    Downloadable Resources

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - VS-0325-FY110.pdf

    MSDS

    MSDS - VS-0325-FY110.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

    Isotype Control

    • CAT
    • Product Name

    Secondary Antibody

    • CAT
    • Product Name

    See other products for "CD3E"

    Select a product category from the dropdown menu below to view related products.

    CAT Product Name Application Type
    TAB-H28 Anti-Human CD3E Recombinant Antibody (Ertumaxomab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG2a / G2b
    CAT Product Name Application Type
    TAB-714 Anti-CD3E Recombinant Antibody (Visilizumab) FuncS, IF, Neut, ELISA, FC, IP, ICC IgG2
    TAB-159 Anti-Human CD3E Recombinant Antibody (TAB-159) Neut, ELISA, IF, IP, FuncS, FC, ICC IgG1 - kappa
    TAB-H52 Anti-Human CD3E Recombinant Antibody (TAB-H52) FC, IP, ELISA, Neut, FuncS, IF, WB IgG1 - lambda
    TAB-420CQ Anti-Human CD3E Recombinant Antibody (Visilizumab) ELISA, IHC, FC, IP, IF, FuncS IgG2, κ
    CAT Product Name Application Type
    TAB-245 Anti-Human CD3 epsilon Recombinant Antibody (TAB-245) WB, ELISA, FC, IP, FuncS, IF, Neut IgG1 - kappa
    TAB-124CL Human Anti-CD3E Recombinant Antibody (TAB-124CL) ELISA Human IgG
    CAT Product Name Application Type
    TAB-019 Anti-Human CD3 Recombinant Antibody (TAB-019) FC, IP, ELISA, Neut, FuncS, IF, WB IgG2a - kappa
    PABX-032-S (P) Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (2C11) WB, ELISA, FuncS scFv
    PABX-033-S (P) Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (17A2) WB, ELISA, FuncS scFv
    CAT Product Name Application Type
    AGTO-G010E Anti-CD3E immunotoxin UCHT1 (scFv)-PE Cytotoxicity assay, Function study
    AGTO-G010D Anti-CD3E immunotoxin UCHT1 (scFv)-DT Cytotoxicity assay, Function study
    AGTO-L049E Anti-CD3E immunotoxin (IgG)-PE Cytotoxicity assay, Functional assay
    AGTO-L049D Anti-CD3E immunotoxin (IgG)-DT Cytotoxicity assay, Functional assay
    AGTO-L049R Anti-CD3E immunotoxin (IgG)-RTA Cytotoxicity assay, Functional assay
    CAT Product Name Application Type
    MOB-0203MC Hamster Anti-CD3E Recombinant Antibody (MOB-0203MC) FC, IHC, IF, IP, WB Hamster IgG
    ZG-0941F Mouse Anti-CD3E Recombinant Antibody (ZG-0941F) FC Mouse IgG
    ZG-0945F Mouse Anti-CD3E Recombinant Antibody (ZG-0945F) FC Mouse IgG
    VS3-XY298 Mouse Anti-CD3E Recombinant Antibody (clone 4E2) ELISA, WB, FC Mouse IgG1
    VS4-WK82 Mouse Anti-CD3E Recombinant Antibody (VS4-WK82) ELISA, IF, FC Mouse IgG2a
    CAT Product Name Application Type
    PFBL-643 Mouse Anti-CD3E Recombinant Antibody (clone 2C11); Fab Fragment WB, IHC, IF, FuncS Mouse Fab
    FAMAB-0047CQ-F(E) Mouse Anti-CD3E Recombinant Antibody (clone CLB-T3/4.1); Fab Fragment ELISA, IF, IP Mouse Fab
    HPAB-0263-YJ-F(E) Rabbit Anti-CD3E Recombinant Antibody (clone 645); Fab Fragment ELISA, FC, FuncS Rabbit Fab
    HPAB-0347-YJ-F(E) Rat Anti-CD3E Recombinant Antibody (clone 1Ab); Fab Fragment FC, WB, Inhib Rat Fab
    HPAB-0385-FY-F(E) Human Anti-CD3E Recombinant Antibody; Fab Fragment (HPAB-0385-FY-F(E)) Activ Human Fab
    CAT Product Name Application Type
    PSBL-643 Mouse Anti-CD3E Recombinant Antibody (clone 2C11); scFv Fragment WB, IHC, IF, FuncS Mouse scFv
    FAMAB-0047CQ-S(P) Mouse Anti-CD3E Recombinant Antibody (clone CLB-T3/4.1); scFv Fragment ELISA, IF, IP Mouse scFv
    HPAB-0263-YJ-S(P) Rabbit Anti-CD3E Recombinant Antibody (clone 645); scFv Fragment ELISA, FC, FuncS Rabbit scFv
    HPAB-0347-YJ-S(P) Rat Anti-CD3E Recombinant Antibody (clone 1Ab); scFv Fragment FC, WB, Inhib Rat scFv
    HPAB-0385-FY-S(P) Human Anti-CD3E Recombinant Antibody; scFv Fragment (HPAB-0385-FY-S(P)) Activ Human scFv
    CAT Product Name Application Type
    PABX-032 Recombinant Grey hamster Anti-CD3E Antibody (2C11) WB, ELISA, FuncS, IP IgG
    PABX-033 Recombinant Grey hamster Anti-CD3E Antibody (17A2) WB, ELISA, FuncS IgG
    PABX-032-F (E) Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (2C11) WB, ELISA, FuncS Fab
    PABX-033-F (E) Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (17A2) WB, ELISA, FuncS Fab
    CAT Product Name Application Type
    MOR-0558 Hi-Affi™ Rabbit Anti-CD3E Recombinant Antibody (clone DS558AB) IHC-P Rabbit IgG
    MOR-0058-FY Rabbit Anti-CD3E Recombinant Antibody (clone AFY0029) FC, ICC, IF, IHC-P, WB Rabbit IgG
    CAT Product Name Application Type
    AFC-TAB-159 Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-159) Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
    AFC-TAB-245 Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-245) ELISA, FC, IP, FuncS, IF ADCC enhanced antibody
    AFC-TAB-H52 Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H52) FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
    AFC-TAB-714 Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-714) FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
    AFC-TAB-019 Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-019) FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
    CAT Product Name Application Type
    VS-0724-XY17 Mouse Anti-CD3E Agonistic Antibody (VS-0724-XY17) FC, IP, ICC, Agonistic assays Mouse IgG1
    CAT Product Name Application Type
    VS-0724-YC1433 AbPlus™ Anti-CD3E Magnetic Beads (VS-0724-YC1433) IP, Protein Purification
    CAT Product Name Application Type
    VS-1024-XY94 Mouse Anti-NHP CD3E Recombinant Antibody (clone FN-18) ELISA Mouse IgG1
    CAT Product Name Application Type
    VS-0225-XY46 CytoStream™ Mouse Anti-CD3E Recombinant Antibody (clone 1F4) FC Mouse IgM, kappa
    VS-0225-XY47 CytoStream™ Mouse Anti-CD3E Recombinant Antibody (clone SK7) FC Mouse IgG1, kappa
    CAT Product Name Application Type
    VS-0425-YC355 Recombinant Anti-CD3E Vesicular Antibody, EV Displayed (VS-0425-YC355) ELISA, FC, Neut, Cell-uptake
    CAT Product Name Application Type
    VS-0525-XY1171 Anti-CD3E Immunohistochemistry Kit IHC
    VS-0525-XY1172 Anti-Mouse CD3E Immunohistochemistry Kit IHC
    Specific Inquiry
    Go to compare Add to compare
    Request
    Custom Production     custom production
    See Our Custom Production in Action
    Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE
    Download the full case study
    Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE
    Download the full case study

    Popular Products

    Figure 1 Anti-C. difficile Toxin A Recombinant Antibody (TAB-716) in SDS-PAGE

    Anti-C. difficile Toxin A Recombinant Antibody (TAB-716) (CAT# TAB-716)
    Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

    Figure 2 Anti-Human SLC34A2 Antibody (TAB-H45) in HPLC

    Human Anti-SLC34A2 Recombinant Antibody (TAB-H45) (CAT# TAB-H45)
    Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

    Figure 2 Anti-Human VEGF therapeutic Antibody Fab Fragment (TAB-012-F(E)) in Dot Blot

    Anti-Human VEGF Recombinant Antibody Fab Fragment (TAB-012-F(E)) (CAT# TAB-012-F(E))
    Application: IP, IF, FuncS, FC, Neut, ELISA, IHC

    Figure 2 Anti-Human IL6R Antibody (TAB-026) in WB

    Anti-Human IL6R Recombinant Antibody (TAB-026) (CAT# TAB-026)
    Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

    Figure 1 Recombinant Human Anti-DENV E proteins Antibody (PABL-067) in SDS-PAGE

    Recombinant Human Anti-DENV E proteins Antibody (5J7) (CAT# PABL-067)
    Application: ELISA, Neut, FuncS

    Figure 3 Anti-CA9 Antibody in Dot Blot.

    Mouse Anti-CA9 Recombinant Antibody (clone M75) (CAT# PABZ-017)
    Application: WB, FuncS

    Figure 3 Human Anti-MS4A1 Recombinant Antibody (PABL-422) in Flow Cytometry

    Human Anti-MS4A1 Recombinant Antibody (clone 2F2) (CAT# PABL-422)
    Application: WB, ELISA, FuncS

    Figure 2 Recombinant Human Anti-TSHR Antibody (PABW-172) in HPLC

    Recombinant Human Anti-TSHR Antibody (M22) (CAT# PABW-172)
    Application: WB, ELISA, PK

    Figure 2 Anti-Human CD47 Recombinant Antibody (TAB-303LC) in ELISA

    Human Anti-CD47 Recombinant Antibody (TAB-303LC) (CAT# TAB-303LC)
    Application: ELISA

    Figure 2 Anti-CLDN4 Antibody (TAB-501LC) in HPLC

    Anti-Human CLDN4 Recombinant Antibody (KM3900) (CAT# TAB-501LC)
    Application: WB, IP, FC

    Figure 5 Anti-Human GM-CSF Recombinant Antibody (F1) in ELISA.

    Anti-Human GM-CSF (Granulocyte-macrophage colony stimulating growth factor) Recombinant Antibody (F1) (CAT# TAB-180CT)
    Application: Neut, Inhib, FC, ELISA

    Figure 2 Recombinant Mouse Anti-HSPA1A Antibody (HPAB-0243-YC) in HPLC

    Mouse Anti-HSPA1A Recombinant Antibody (HPAB-0243-YC) (CAT# HPAB-0243-YC)
    Application: ELISA, FC

    Figure 2 Recombinant Anti-ICAM1 Single Domain Antibody (HPAB-0349-YC-VHH) in ELISA

    Recombinant Llama Anti-ICAM1 Single Domain Antibody (HPAB-0349-YC-VHH) (CAT# HPAB-0349-YC-VHH)
    Application: ELISA

    Figure 5 Human Anti-FAP Recombinant Antibody (HPAB-0175-CN) in ELISA

    Human Anti-FAP Recombinant Antibody (clone ESC14) (CAT# HPAB-0175-CN)
    Application: ELISA, WB, FC, IHC, IP

    Figure 3 Anti-MAPT Recombinant Antibody (NS-090CN) in ELISA

    Mouse Anti-MAPT Recombinant Antibody (NS-090CN) (CAT# NS-090CN)
    Application: WB, ELISA, IHC, IP, SPR, FuncS

    Figure 3 Anti-IL2 Recombinant Antibody (PABC-506) in DB

    Human Anti-IL2 Recombinant Antibody (PABC-506) (CAT# PABC-506)
    Application: Inhib, ELISA, FC, FuncS

    Figure 2 Human Anti-HLA-A2-Mart-1 Complex Recombinant Antibody (HPAB-N0135-YC) in HPLC

    Human Anti-HLA-A2-Mart-1 Complex Recombinant Antibody (clone CLA12) (CAT# HPAB-N0135-YC)
    Application: ELISA, FC

    Figure 2 Human Anti-HLA-DR4 Recombinant Antibody (HPAB-0826-FY) in HPLC

    Human Anti-HLA-DR4/GAD-555-567 Recombinant Antibody (clone G3H8) (CAT# HPAB-0826-FY)
    Application: FC

    Figure 2 Human Anti-HLA-DR4 Recombinant Antibody (HPAB-0827-FY) in HPLC

    Human Anti-HLA-DR4/GAD-555-567 Recombinant Antibody (clone G1H12) (CAT# HPAB-0827-FY)
    Application: FC

    Figure 2 Anti-FAP Antibody in ELISA.

    Mouse Anti-FAP Recombinant Antibody (clone F19) (CAT# HPAB-A1368-YJ)
    Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block

    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

    Send Inquiry

    This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

    Go to compare

    Go to compare