Anti-CD3E Recombinant Antibody (Visilizumab)
CAT#: TAB-714
Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD3 receptor. Visilizumab is a humanized monoclonal antibody. It is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn's disease.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line JURKAT
Immunofluorescent staining of human cell line JURKAT shows localization to plasma membrane & endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40957/1970_E5_1_selected.jpg
Normal Tissue
Figure 2 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72864/157655_A_9_8.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198851-CD3E
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG2
- Species Reactivity
- Human
- Applications
- Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
- Trade name
- nuvion
- CAS
- 219716-33-3
- Generic Name
- visilizumab
- Related Disease
- Kidney transplantation
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- visilizumab;nuvion;219716-33-3;HuM291;SMART Anti-CD3;CD3E;CD3e molecule, epsilon (CD3-TCR complex);CD3e antigen, epsilon polypeptide (TiT3 complex);T-cell surface glycoprotein CD3 epsilon chain;CD3-epsilon;T-cell surface antigen T3/Leu-4 epsilon chain;T-c
- Gene ID
- 916
- UniProt ID
- P07766
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Biosimilar Overview
Please refer to Visilizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Visilizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Visilizumab"
Anti-Human CD3E Recombinant Antibody (Visilizumab)Recombinant monoclonal antibody to CD3E. Visilizumab is a humanized monoclonal antibody that can be potentially used in the treatment of Allograft rejection, Psoriasis, Autoimmune diseases.
Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-714)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD3 receptor. It is a humanized monoclonal antibody. It is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn's disease.
DrugMonitor™ Anti-Visilizumab Antibody (VS-1224-YC1307)Visilizumab has been investigated for ulcerative colitis treatment. The DrugMonitor™ Anti-Visilizumab Antibody (VS-1224-YC1307) is an anti-drug antibody (ADA) against Visilizumab. This drug-based antibody is raised in mice immunized with the Visilizumab. The anti-Visilizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Visilizumab in samples.
See other products for "CD3E"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H28 | Anti-Human CD3E Recombinant Antibody (Ertumaxomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG2a / G2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-988 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1) | FC, IHC, WB, FuncS, IF | Mouse IgG1 F(ab')2 |
| DrMAB-989 | Mouse Anti-CD3E Recombinant Antibody (clone UCHT1); Fab Fragment | FC, Cyt, Stim, PP, Agonist | Mouse Fab |
| FAMAB-0049-YC-F(E) | Hamster Anti-CD3E Recombinant Antibody Fab Fragment (FAMAB-0049-YC-F(E)) | FC, FuncS | Hamster Fab |
| FAMAB-0052-YC-F(E) | Hamster Anti-CD3E Recombinant Antibody (clone 500A2); Fab Fragment | ELISA | Hamster Fab |
| HPAB-0385-FY-F(E) | Human Anti-CD3E Recombinant Antibody; Fab Fragment (HPAB-0385-FY-F(E)) | Activ | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-159 | Anti-Human CD3E Recombinant Antibody (TAB-159) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
| TAB-H52 | Anti-Human CD3E Recombinant Antibody (TAB-H52) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - lambda |
| TAB-420CQ | Anti-Human CD3E Recombinant Antibody (Visilizumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-245 | Anti-Human CD3 epsilon Recombinant Antibody (TAB-245) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG1 - kappa |
| TAB-124CL | Human Anti-CD3E Recombinant Antibody (TAB-124CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-019 | Anti-Human CD3 Recombinant Antibody (TAB-019) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG2a - kappa |
| PABX-032-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (2C11) | WB, ELISA, FuncS | scFv |
| PABX-033-S (P) | Recombinant Grey hamster Anti-CD3E Antibody scFv Fragment (17A2) | WB, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G010E | Anti-CD3E immunotoxin UCHT1 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G010D | Anti-CD3E immunotoxin UCHT1 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-G010R | Anti-CD3E immunotoxin UCHT1 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-L049E | Anti-CD3E immunotoxin (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L049D | Anti-CD3E immunotoxin (IgG)-DT | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-643 | Mouse Anti-CD3E Recombinant Antibody (clone 2C11); scFv Fragment | WB, IHC, IF, FuncS | Mouse scFv |
| FAMAB-0049-YC-S(P) | Hamster Anti-CD3E Recombinant Antibody scFv Fragment (FAMAB-0049-YC-S(P)) | FC, FuncS | Hamster scFv |
| FAMAB-0052-YC-S(P) | Hamster Anti-CD3E Recombinant Antibody (clone 500A2); scFv Fragment | ELISA | Hamster scFv |
| HPAB-0263-YJ-S(P) | Rabbit Anti-CD3E Recombinant Antibody (clone 645); scFv Fragment | ELISA, FC, FuncS | Rabbit scFv |
| HPAB-0347-YJ-S(P) | Rat Anti-CD3E Recombinant Antibody (clone 1Ab); scFv Fragment | FC, WB, Inhib | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-032 | Recombinant Grey hamster Anti-CD3E Antibody (2C11) | WB, ELISA, FuncS, IP | IgG |
| PABX-033 | Recombinant Grey hamster Anti-CD3E Antibody (17A2) | WB, ELISA, FuncS | IgG |
| PABX-032-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (2C11) | WB, ELISA, FuncS | Fab |
| PABX-033-F (E) | Recombinant Grey hamster Anti-CD3E Antibody Fab Fragment (17A2) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0558 | Hi-Affi™ Rabbit Anti-CD3E Recombinant Antibody (clone DS558AB) | IHC-P | Rabbit IgG |
| MOR-0058-FY | Rabbit Anti-CD3E Recombinant Antibody (clone AFY0029) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-159 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-159) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-245 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-245) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-H52 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H52) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-714 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-714) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-019 | Afuco™ Anti-CD3E ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-019) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-201CQ | Hamster Anti-CD3E Recombinant Antibody (clone CBL-1334) | FC, FuncS, IHC-Fr | Syrian hamster IgG |
| ZG-0941F | Mouse Anti-CD3E Recombinant Antibody (ZG-0941F) | FC | Mouse IgG |
| ZG-0945F | Mouse Anti-CD3E Recombinant Antibody (ZG-0945F) | FC | Mouse IgG |
| VS-0624-FY4 | Rabbit Anti-CD3E Recombinant Antibody (clone-2) | FC, ELISA | Rabbit IgG |
| VS7-HM585 | Mouse Anti-CD3E Recombinant Antibody (clone CBL123HM) | WB, FCM, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY17 | Mouse Anti-CD3E Agonistic Antibody (VS-0724-XY17) | FC, IP, ICC, Agonistic assays | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1433 | AbPlus™ Anti-CD3E Magnetic Beads (VS-0724-YC1433) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY94 | Mouse Anti-NHP CD3E Recombinant Antibody (clone FN-18) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY46 | CytoStream™ Mouse Anti-CD3E Recombinant Antibody (clone 1F4) | FC | Mouse IgM, kappa |
| VS-0225-XY47 | CytoStream™ Mouse Anti-CD3E Recombinant Antibody (clone SK7) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY110 | Human Anti-CD3E (clone NI-0401) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC355 | Recombinant Anti-CD3E Vesicular Antibody, EV Displayed (VS-0425-YC355) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1171 | Anti-CD3E Immunohistochemistry Kit | IHC | |
| VS-0525-XY1172 | Anti-Mouse CD3E Immunohistochemistry Kit | IHC |
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