Mouse Anti-GXM Recombinant Antibody (clone 12A1) (CAT#: FAMAB-0564WJ)
This product is a mouse monoclonal antibody that is specific for C. neoformans GXM. This antibody can be used in a variety of applications, such as ELISA, WB, IF, Neut.
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Figure 1 GXM concentration in the supernatant of C. neoformans H99 cultures in the presence and absence of IgM-specific MAbs.
The inset graphs correspond to capsule size measurements of C. neoformans H99 cells. Bars are the average of three GXM concentration measurements, and brackets denote standard deviations. Asterisks denote P value significance calculated by analysis of variance and adjusted by the Bonferroni correction. The experiment was done four times, with similar results. Ab, antibody.
Martinez, L. R., Moussai, D., & Casadevall, A. (2004). Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen. Infection and immunity, 72(6), 3674-3679.
Figure 2 GXM concentration in the supernatant of C. neoformans 24067 cultures in the presence and absence of IgM-specific MAbs.
The inset graphs correspond to capsule size measurements of C. neoformans 24067 cells. Bars are the average of three GXM concentration measurements, and brackets denote standard deviations. Asterisks denote P value significance calculated by analysis of variance and adjusted by the Bonferroni correction. The experiment was done four times, with similar results. Ab, antibody.
Martinez, L. R., Moussai, D., & Casadevall, A. (2004). Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen. Infection and immunity, 72(6), 3674-3679.
IF
Figure 3 Indirect immunofluorescence capsular pattern with mAbs 12A1 and 13F1 on different C. neoformans serotype A and D strains.
Martinez, L. R., Moussai, D., & Casadevall, A. (2004). Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen. Infection and immunity, 72(6), 3674-3679.
Figure 4 Immunoelectron micrograph of the cryptococcal serotype D strain 24067 capsule immunostained with gold-labeled 12A1.
Martinez, L. R., Moussai, D., & Casadevall, A. (2004). Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen. Infection and immunity, 72(6), 3674-3679.
FuncS
Figure 5 Survival of A/J mice after intraperitoneal treatment with the IgM mAbs 12A1 and 13F1 preceding infection with C. neoformans.
(A) serotype D strain 34873, (B) serotype A strain J11.
Martinez, L. R., Moussai, D., & Casadevall, A. (2004). Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen. Infection and immunity, 72(6), 3674-3679.
Figure 6 Opsonic activity of mAbs 12A1 and 13F1 in the presence of J774.16 macrophages on C. neoformans serotype D strain 24067.
Martinez, L. R., Moussai, D., & Casadevall, A. (2004). Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen. Infection and immunity, 72(6), 3674-3679.
Figure 7 Opsonic activity of mAbs 12A1 and 13F1 in the presence of J774.16 macrophages on C. neoformans serotype A strain J11.
Martinez, L. R., Moussai, D., & Casadevall, A. (2004). Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen. Infection and immunity, 72(6), 3674-3679.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgM
- Specificity
- C. neoformans GXM
- Species Reactivity
- C. neoformans
- Clone
- 12A1
- Applications
- ELISA, WB, IF, Neut
- Related Disease
- C. neoformans infection
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- C. neoformans GXM; GXM
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgM Antibody Products
ScFv Antibody Products
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0062-CN | Human Anti-GXM Recombinant Antibody (clone G19) | FC, Inhib | Human IgM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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